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Figure 2 Shows that Sativex had no significant effects on resting motor threshold (RMT), motor evoked potential (MEP) amplitude, and RIII threshold in.

Published byKristina Cleopatra Fletcher Modified over 6 years ago

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Presentation on theme: "Figure 2 Shows that Sativex had no significant effects on resting motor threshold (RMT), motor evoked potential (MEP) amplitude, and RIII threshold in."— Presentation transcript:

1 Figure 2 Shows that Sativex had no significant effects on resting motor threshold (RMT), motor evoked potential (MEP) amplitude, and RIII threshold in both pain and no pain-MS patients. Values are reported as percent variation of the unconditioned value at baseline (PRE). Evaluating Sativex ® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis Pain Med. 2016;17(6): doi: /pm/pnv080 Pain Med | © 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please

2 Figure 3 Shows the gamma-band oscillations (γ-BO) at PRE (left panel) and the perceived pain rating (I) while increasing the energy of laser stimulation (right panel). Pain MS patients showed at PRE a more variable γ-BO than no pain-MS. Monthly Sativex administration restored the I-γ-BO relation, and increased it in no pain-MS. Values are reported as percent value. Evaluating Sativex ® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis Pain Med. 2016;17(6): doi: /pm/pnv080 Pain Med | © 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please

3 Figure 4 Pain MS patients showed at baseline (PRE) a low PMI in comparison to no pain-MS individuals. The Sativex intake restored PMI strength in pain MS patients. Values are reported as percent variation of the unconditioned MEP at PRE. Evaluating Sativex ® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis Pain Med. 2016;17(6): doi: /pm/pnv080 Pain Med | © 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please

4 Figure 5 Reports the Sativex effects on laser-evoked potentials (LEP) latency and amplitude. We observed a reduction of LEP latency only in no pain-MS group. Values are reported as mean absolute values. Evaluating Sativex ® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis Pain Med. 2016;17(6): doi: /pm/pnv080 Pain Med | © 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please

5 Figure 1 Shows the clinical effects after 4 weeks of Sativex administration (POST) in both pain and no pain-MS patients. NRS and MAS significantly decreased (* P < 0.05) in both groups, whereas VAS improved only in pain MS patients. EDSS: expanded disability status scale; MAS: modified Ashworth scale; VAS: visual analog scale; NRS: numerical rating scale. Values are reported as percent variation of the unconditioned value at baseline (PRE). Evaluating Sativex ® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis Pain Med. 2016;17(6): doi: /pm/pnv080 Pain Med | © 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please

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