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Figure 7. Cycloheximide blocks the potentiation of insulin action by MCC-555. Cardiomyocytes were subjected to the indicated incubation conditions using.

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Presentation on theme: "Figure 7. Cycloheximide blocks the potentiation of insulin action by MCC-555. Cardiomyocytes were subjected to the indicated incubation conditions using."— Presentation transcript:

1 Figure 7. Cycloheximide blocks the potentiation of insulin action by MCC-555. Cardiomyocytes were subjected to the indicated incubation conditions using insulin (10<sup>−7</sup>m) for 5 min and MCC-555 (100 μm) and cycloheximide (1 mm) for 30 min. Initial rates of 3-OMG transport were then determined, as outlined in Fig. 2. Glucose transport is expressed as a percentage of basal uptake, which was determined in the absence of any addition. Data are the mean ± sem (n = 3–4). *, Significantly different from transport stimulation determined in the presence of cycloheximide (P = ). The New Antidiabetic Drug MCC-555 Acutely Sensitizes Insulin Signaling in Isolated Cardiomyocytes**This work was supported by the Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen, the Bundesministerium für Gesundheit, EU COST Action B5, and a grant from Mitsubishi Chemical (Yokohama, Japan). Endocrinology. 1998;139(11): doi: /endo Endocrinology | Copyright © 1998 by The Endocrine Society 1

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