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C. Neuronal activity of cortical and thalamic neurons becomes synchronized during a primary generalized seizure. The depolarization is dependent on conductances.

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Presentation on theme: "C. Neuronal activity of cortical and thalamic neurons becomes synchronized during a primary generalized seizure. The depolarization is dependent on conductances."— Presentation transcript:

1 C. Neuronal activity of cortical and thalamic neurons becomes synchronized during a primary generalized seizure. The depolarization is dependent on conductances in AMPA-type glutamate receptor-channels and T-type voltage-gated Ca2+ channels. The repolarization is caused by GABA-mediated inhibition as well as voltage- and calcium-dependent K+ conductances (g K). (Reproduced, with permission, from Lothman 1993a.) Source: Seizures and Epilepsy, Principles of Neural Science, Fifth Editon Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available at: Accessed: November 12, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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