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Blood Cytokines during the Perinatal Period in Very Preterm Infants: Relationship of Inflammatory Response and Bronchopulmonary Dysplasia Reija Paananen, PhD, Anna-Karin Husa, MSc, Reetta Vuolteenaho, PhD, Riitta Herva, MD, PhD, Tuula Kaukola, MD, PhD, Mikko Hallman, MD, PhD The Journal of Pediatrics Volume 154, Issue 1, Pages e3 (January 2009) DOI: /j.jpeds Copyright © 2009 Mosby, Inc. Terms and Conditions
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Figure 1 Concentration of plasma cytokines during the perinatal transition of VLGA infants born with CA (n = 48) and without CA (no CA; n = 75). The results for infants developing BPD (n = 32) and for infants with no BPD (n = 91) are shown. Plasma concentrations (pg/mL) are shown as box blots: medians, interquartile ranges, 10th and 90th percentiles, and means. *Significant (P < .05) and **very significant (P < .01) differences between the 2 groups (covariance analysis, using gestation at birth as covariate). The Journal of Pediatrics , e3DOI: ( /j.jpeds ) Copyright © 2009 Mosby, Inc. Terms and Conditions
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Figure 2 ROC analysis of the risk of BPD for infants born with CA and those without CA (no CA). Mean plasma IL-8 concentration at age 1 day (A, 83.3 [41.2 to 151] pg/ml; B, 98.9 [51.8 to 211]) and mean oxidation index during the first day (C, 26.6 [19.7 to 50.5 cmH2O/kPa]; D, 31.0 [16.4 to 48.0]) were evaluated. The areas under the ROC curves (mean ± standard error) were as follows: A, ± 0.076, P = .034; B, ± 0.053, P < .0001; C, ± 0.083, P = .028; D, ± 0.058, P = The Journal of Pediatrics , e3DOI: ( /j.jpeds ) Copyright © 2009 Mosby, Inc. Terms and Conditions
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