1. Applications of Pharmacokinetics

2. Rational & Optimal therapy Right Balance between Therapeutic & Tox
Applications of Pharmacokinetics
Right DRUG
Rational & Optimal therapy
Right Balance between Therapeutic & Tox

3. Applications of Pharmacokinetics Ratio
Right Balance between Therapeutic & Tox effects
Drug Concentration at Site
Drug Concentration in Plasma

4. Applications of Pharmacokinetics
Ratio
Applications of Pharmacokinetics
Max effective conc
This is where we want to maintain drug concentration for optimal benefit
Therapeutic Window
Drug Conc
Minimum effective conc
Time

5. Applications of Pharmacokinetics
Ratio
So for optimal dosing, we need to know mechanism of ADME as well as “KINETICS” of ADME
Max effective conc
This is where we want to maintain drug concentration for optimal benefit
Therapeutic Window
Drug Conc
Minimum effective conc
Time

6. Key Pharmacokinetic Parameters
Ratio
Cmax
Maximum drug conc, peak plasma conc
Cmax depends on
Dose
Rate of absorption
Rate of elimination
At Cmax; Rate of absorption = Rate of elimination
Ideally, Min effect conc < Cmax < Max effective conc
Drug Conc
Time

7. Key Pharmacokinetic Parameters
Ratio
Tmax
Time to reach peak plasma conc
Reflects rate of absorption
Onset time, Onset of action depends on Tmax
Drug Conc
Tmax
Time

8. Key Pharmacokinetic Parameters
Ratio
AUC
Area Under the curve
Represents amount of drug that enters systemic circulation after administration
Represents extent of absorption
Important parameter to estimate bioavailability
Drug Conc
Time

9. Pharmacokinetic Analysis
Ratio
Pharmacokinetic Analysis
Drug absorption, distribution, elimination is complex process
We need simple approach to
DESCRIBE,
ANALYSE &
INTERPRET PK data
Drug Conc
Time

10. Pharmacokinetic Analysis
Ratio
Pharmacokinetic Analysis
Two major approaches to quantitative study of PK data
Model Based approach
Model-Independent approach
Drug Conc
Time

11. That uses mathematical terms
Ratio
Model- Based approach
What's a PK MODEL ??
It’s a HYPOTHESIS
Drug Conc
That uses mathematical terms
To describe PK data
Time
Hypothesis is a proposed explanation, in this case of drug ADME process

12. Ratio
Types of PK Models
Compartment Model
Physiological Model

13. What are Compartment Model ?
Ratio
What are Compartment Model ?
As the name suggest, body is assumed to be made up of “Compartments”
These compartment are connected to each other
Within each compartment, the drug get’s rapidly distributed & uniformly distributed (Well stirred model)

14. THANK YOU -PHARMA STREET