1. © The Author(s) 2014. Published by Science and Education Publishing.
Table 3. Application of the developed HPLC method for the determination of sodium hyaluronate in active pharmaceutical ingredient and ophthalmic solution
Manufacturer
Country of origin
Trade name
Conc.(mg/mL) a
Assay(%) A
Assay(%) B
Sun Pharma
India
Hyvisc
0.10
99.24a
99.85a
URASAPHARM
Germany
Hylo-comp
99.18a
99.56a
Moorfields Pharmaceuticals
United kingdom
Lubristil
0.15
98.21a
99.42a
Croma-Pharma GmbH
Olixia pure
99.14a
99.46a
TRB Chemedica (UK) Ltd
Vismed
0.18
98.64a
98.75a
Altacor Limited
Clinitas
0.40
99.88a
100.2a
Butterflies Healthcare Ltd
Ocusan
0.20
99.23a
99.51a
FDC Limited
Hymoist
99.62a
99.26a
Hyvisc Plus
99.11a
98.23a
In-house Room Temperature
Saudi Arabia
Hyfresh
99.06a
99.75a
In-house accelerated condition
99.43a
99.64a
Lot Ab
China
Yantai Dongcheng Biochemicals
----
99.55c
99.32c
Lot Bb
------
99.83c
100.1c
a: each value is average of two determinations (n=2); b: Active pharmaceutical ingredient; c= calculated on dry basis
A: Assay proposed method B: Assay by HPLC method
K. Ruckmani et al. A New Simple and Rapid Method for the Determination of Sodium Hyaluronate in Active Pharmaceutical Ingredient and Ophthalmic Formulations by DP5 Photorode. World Journal of Analytical Chemistry, 2014, Vol. 2, No. 2, doi: /wjac-2-2-1
© The Author(s) Published by Science and Education Publishing.