1. Scenario 1: Diagnostic No PCI Required
Left Coronary Artery (LCA)
Right Coronary Artery (RCA)
LCX
50mm
RCA
65mm GC GC
LAD
70mm
Study Segment Qualifications:
At least one Suspected Index Culprit Lesion (LAD)
At least two major epicardial vessels eligible for IVUS-NIRS Imaging (RCA , LAD, LCX)
At least 50mm total pullback (Visually estimated LAD 70mm pullback, LCX 50 mm pullback, RCA 65mm. Approximate total 185mm pullback of scanned coronary artery)
Total Eligible Length (excludes stents & borders) = ~185mm
Suspected Index Culprit Lesion: Prox LAD
Unblinded Run: LAD
Index Non-Culprit Artery: RCA, LCX
Blinded Run(s): LCX, RCA
PCI Performed: No PCI performed
= Suspected Index
Culprit Lesion
= Blinded Scan
= Guide Catheter
= Unblinded Scan
= 5mm excluded stent
border
= Treated Segment;
scanned but not
included in analysis
XXXXX= Stent

2. Scenario 2: Single Lesion PCIGC
LCA
RCA
LAD
45mm GC
LCX
60mm
RCA
50mm
Total Eligible Length (excluding stent & borders) = ~155mm
Suspected Index Culprit Lesion: RCA
Unblinded Run: RCA
Index Non-Culprit Artery: LAD, LCX
Blinded Run(s): LCX, LAD
PCI Performed On: Prox RCA
XXXXX GC
Study Segment Qualifications:
At least one Suspected Index Culprit Lesion (RCA)
At least two major epicardial vessels eligible for IVUS-NIRS Imaging (RCA , LAD, LCX)
At least 50mm total pullback (Visually estimated LAD 45mm pullback, LCX 60 mm pullback, RCA 50mm. Approximate total 155mm pullback of scanned coronary artery)
Exclude 5mm borders
= Suspected Index
Culprit Lesion
= Blinded Scan
= Guide Catheter
= Unblinded Scan
= 5mm excluded stent
border
= Treated Segment;
scanned but not
included in analysis
XXXXX = Stent
RCA
50mm

3. Scenario 3: Chronic Total Occlusion
RCA GC
LCA
RCA GC
CTO
LAD
35mm
LCX
55mm
RCA GC
Study Segment Qualifications:
At least one Suspected Index Culprit Lesion (RCA)
At least two major epicardial vessels eligible for IVUS-NIRS Imaging (LAD, LCX)
At least 50mm total pullback (Visually estimated LAD 35mm pullback, LCX 55 mm pullback. Approximate total 90mm pullback of scanned coronary artery)
Total Eligible Legth (exluding stents & borders) = ~90mm
Suspected Index Culprit Lesion: RCA
Unblinded Run: RCA
Index Non-Culprit Artery: LAD, LCX
Blinded Run(s): LCX, LAD
PCI Performed On: Prox RCA
RCA GC
=Suspected Index
Culprit Lesion
= Blinded Scan
XXXXXXXXXXX
= Guide Catheter
= Unblinded Scan
Exclude 5mm borders
= Treated Segment;
scanned but not
included in analysis
= 5mm excluded stent
border
XXXXX = Stent

4. Scenario 4: Ramus Present
LCA
RCA
LAD
45mm GC GC
RCA
70mm
LCX
55mm
Ramus
20mm
Study Segment Qualification:
At least one Suspected Index Culprit Lesion (LCX)
At least two major epicardial vessels eligible for IVUS-NIRS Imaging (RCA , LAD, LCX, Ramus)
At least 50mm total pullback (Visually estimated LAD 45mm pullback, LCX 55 mm pullback, RCA 70mm, Ramus 20mm. Approximate total 190mm pullback of scanned coronary artery)
Total Eligible Length (excluding stent & borders)= ~190mm
Suspected Index Culprit Lesion: Prox LCX
Unblinded Run: LCX
Index Non-Culprit Artery: LAD, RCA, Ramus
Blinded Run: LAD, RCA, Ramus
PCI Performed On: No PCI performed
= Suspected Index
Culprit Lesion
= Blinded Scan
= Guide Catheter
= Unblinded Scan
= 5mm excluded stent
border
= Treated Segment;
scanned but not
included in analysis
XXXXX = Stent

5. Scenario 5: Multi Lesion PCI
LCA
RCA GC GC
Total Eligible Lengh (excluding stent & borders)= ~75mm
Suspected Index Culprit Lesion: LAD, RCA
Unblinded Run: LAD, RCA
Index Non-Culprit Artery: Prox RCA
Blinded Run: N/A
PCI Performed On: Prox RCA and Prox/Mid LAD
LAD
25mm
RCA
50mm
= Suspected Index
Culprit Lesion
Exclude 5mm
borders
Study Segment Qualifications:
At least one Suspected Index Culprit Lesion (LAD, RCA)
At least two major epicardial vessels eligible for IVUS-NIRS Imaging (RCA , LAD)
At least 50mm total pullback (Visually estimated LAD 25mm pullback, RCA 50mm. Approximate total 75mm pullback of scanned coronary artery)
Exclude 5mm borders
= Unblinded Scan
XXXXXX
= Treated Segment;
scanned but not
included in analysis GC
XXXXX
LAD
25mm
= Blinded Scan GC
= Guide Catheter
XXXXXX
= 5mm excluded stent
border
RCA
50mm
XXXXX = Stent

6. Scenario 6: Prior Stenting
LCA
RCA
XXX GC GC
LAD
35mm
XXXXXXXXXXXXX
Exclude 5mm borders
RCA
15mm
LCX
40mm
Study Segment Qualifications:
At least one Suspected Index Culprit Lesion (LAD, RCA)
At least two major epicardial vessels eligible for IVUS-NIRS Imaging (RCA , LAD, LCX)
At least 50mm total pullback (Visually estimated LAD 35mm pullback, RCA 15mm, LCX 40mm. Approximate total 90mm pullback of scanned coronary artery)
Total Eligible Length (exluding stent & borders) = ~90mm
Suspected Index Culprit Lesion: LAD, RCA
Unblinded Run: LAD, RCA
Index Non-Culprit Artery: LCX
Blinded Run: LCX
PCI Performed On: No PCI
= Suspected Index
Culprit Lesion
= Blinded Scan
= Guide Catheter
= Unblinded Scan
= 5mm excluded stent
border
= Treated Segment;
scanned but not
included in analysis
XXXXX = Stent

7. Scenario 7: Single Lesion PCI and Ramus
LCA
RCA
LAD
Ramus
35mm
RCA
80mm
LCX
40mm
LCX
Total Eligible Length (excluding stent & borders)= ~180mm
Suspected Index Culprit Lesion: LAD
Unblinded Run: LAD
Index Non-Culprit Artery: LCX, RCA, Ramus
Blinded Run: LCX, RCA, Ramus
PCI Performed On: Prox LAD
Exclude 5mm borders
LAD
25mm
Study Segment Qualifications:
At least one Suspected Index Culprit Lesion (LAD)
At least two major epicardial vessels eligible for IVUS-NIRS Imaging (RCA , LAC, LCX)
At least 50mm total pullback (Visually estimated LAD 25mm pullback, LCX 40 mm pullback, RCA 80mm, Ramus 35mm. Approximate total 180mm pullback of scanned coronary artery)
XXXXX
= Suspected Index
Culprit Lesion
= Blinded Scan
Ramus
35mm
= Guide Catheter
= Unblinded Scan
= 5mm excluded stent
border
LCX
40mm
= Treated Segment;
scanned but not
included in analysis
XXXXX= Stent