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Figure 3. Sensitivity of the gastric carcinoma cell line N87 for trastuzumab in comparison with the breast cancer cell line SKBR-3. (A) Dose–response curves.

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Presentation on theme: "Figure 3. Sensitivity of the gastric carcinoma cell line N87 for trastuzumab in comparison with the breast cancer cell line SKBR-3. (A) Dose–response curves."— Presentation transcript:

1 Figure 3. Sensitivity of the gastric carcinoma cell line N87 for trastuzumab in comparison with the breast cancer cell line SKBR-3. (A) Dose–response curves were determined by calculating cell counts using a hemocytometer. (B) Growth curves of N87 subcutaneous xenograft tumors in control (upper curve, rituximab treated, n=3) and trastuzumab-treated (lower curve, n=4) NMRI nude mice. Intraperitoneal treatment was initiated at day 14 and continued weekly using a dose of 5 mg/kg per week. From: Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIα gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab Ann Oncol. 2005;16(2): doi: /annonc/mdi064 Ann Oncol | © 2005 European Society for Medical Oncology

2 Figure 1. Kaplan–Meier survival curves (A) of 131 patients with HER-2 amplification (n=16) and normal HER-2 (n=115) in gastric adenocarcinoma and (B) of 65 patients with HER-2 amplification (n=14) and normal HER-2 (n=51) in gastric adenocarcinoma of the intestinal type. From: Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIα gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab Ann Oncol. 2005;16(2): doi: /annonc/mdi064 Ann Oncol | © 2005 European Society for Medical Oncology

3 Figure 2. Mean expression levels of (A) HER-2/neu and (B) HER-1, HER-3 and HER-4 mRNA in a gastric carcinoma cell line N87 (gray bar) and in breast cancer cell lines SKBR-3 (black bar) and T47D (white bar). Protein expression of HER1, p185<sup>HER-2/neu</sup>, HER3 and HER4 by western analyses of the cell lines is shown in (C). From: Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIα gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab Ann Oncol. 2005;16(2): doi: /annonc/mdi064 Ann Oncol | © 2005 European Society for Medical Oncology

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