1. From: Optical Effects of Anti-TGFβ Treatment after Photorefractive Keratectomy in a Cat Model
Invest. Ophthalmol. Vis. Sci ;50(2): doi: /iovs
Figure Legend:
In vivo confocal imaging 20 μm below the epithelial-stromal interface. (A–D) Images of the right eye (OD) of the cat in Figure 2 , which was treated with −10-D PRK and anti-TGFβ dexamethasone after surgery, and demonstrating the radical change in reflectivity in this corneal region over time. (E–H) Images of the left eye (OS) of the same cat, which received only vehicle solution after the −10-D PRK. Images were also collected before surgery, and then at 2, 4, and 12 weeks after PRK. The well-organized, regular syncytium of quiescent keratocytes before surgery contrasted with the less regular, reactive, and strongly reflective activated keratocytes and myofibroblasts that replace it after surgery, particularly in the control (left) eye. Indeed, the control eye exhibited much stronger reflectivity and cellularity than the anti-TGFβ-treated eye, especially at 2 and 4 weeks after PRK. There were spindle-shaped migratory fibroblasts (arrow) and the cluster of reflective activated keratocytes in the right eye at 2 weeks after PRK. Clustering was still present in anti-TGFβ-treated eyes 4 weeks after PRK, but was not seen in control eyes. As is evident in this set of images, control eyes exhibited greater cell density and greater reflectivity at this corneal depth than did eyes treated with anti-TGFβ/dexamethasone, at all postoperative time points.
Date of download: 11/13/2017
The Association for Research in Vision and Ophthalmology Copyright © All rights reserved.