1. In the name of GOD Blood Circulation 3
Dr. Radmanesh

2. The Microcirculation and vasomotion

3. Arterioles and Capillaries
Figure 8.2

5. Transendothelial exchange inter-endothelial cell clefts
paracellular
transcellular
vesicles
fenestra
inter-endothelial cell clefts

6. Transport Mechanisms Diffusion Intercellular Clefts
Plasmalemmal Vesicles
“Tight Junctions” (brain)
Open Junctions (liver)
Fenestra (kidney)

10. Diffusion through Capillary Membrane
This figure illustrates that the permeability of substances through capillary membrane decreases roughly with the logarithm of size.

11. Fluid Filtration Across Capillaries

14. NFP= (Pc +if ) – (p + Pif )

15. Filtration= K * NFP

16. V = Kf [ ( Pc +if ) – (p + Pif ) ]
V= K * NFP

22. On the arteriole end, the hydrostatic pressure is higher than the oncotic, so there is fluid movement from plasma to interstitium.  The magnitude of this water flow is indicated by the light blue area on the left (downward arrows). On the venule end, the hydrostatic pressure has dropped below the oncotic pressure.  Fluid moves back from the interstitium to the plasma. The magnitude of this reverse flow is indicated by the green area on the right (upward arrows).  

25. factor that increases interstitial fluid pressure :
increases lymph flow
Elevated capillary pressure
Decreased plasma colloid osmotic pressure
Increased interstitial fluid colloid osmotic pressure
Increased permeability of the capillaries

27. Summary of Factors That Determine Lymph Flow
(1) the interstitial fluid pressure
(2) the activity of the lymphatic pump.
the rate of lymph flow is determined by
the product of interstitial fluid pressure times the activity of the lymphatic pump.

30. Causes of Edema Increase capillary pressure
Increase capillary permeability
Decrease colloidal osmotic pressure
Obstruction of lymphatic flow