1. Expression of stem cell markers in oral cavity and oropharynx squamous cell carcinoma 
Flávia Paiva Prudente de Moraes, MD, Silvia Vanessa Lourenço, PhD, Renata Carolina Fraga Ianez, PhD, Elen Alves de Sousa, MSc, Marlon Messias da Conceição Silva, BSc, Aline Santos Damascena, BSc, Luiz Paulo Kowalski, MD, PhD, Fernando Augusto Soares, MD, PhD, Cláudia Malheiros Coutinho-Camillo, PhD 
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 
Volume 123, Issue 1, Pages (January 2017)
DOI: /j.oooo
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2. Fig. 1
Expression of CD29 (integrin-β1), CD44, ALDH1, CD24, CD133, and Ki-67 in oral cavity and oropharynx squamous cell carcinoma samples. A, CD29 membrane expression in basal and parabasal layers of non-neoplastic oral mucosa (original magnification ×400); B, Membranous CD29 expression in a squamous cell carcinoma (SCC) island (original magnification ×400); C, CD29 expression in lymph node parenchyma: Note the absence of CD29 expression in tumor islands (original magnification ×150); D, CD44 expression in basal and parabasal layers of non-neoplastic oral mucosa (original magnification ×400); E, Focal, membranous CD44 expression in tumor islands (original magnification ×400); F, SCC lymph node invasion: expression of CD44 in neoplastic cell membranes (original magnification ×250); G, aldehyde dehydrogenase 1 (ALDH1) expression in basal and parabasal layers of non-neoplastic oral mucosa (original magnification ×400); H, Strong ALDH1 expression in tumor islands (original magnification ×250); I, ALDH1 expression in isolated tumor islands (original magnification ×400); J, Non-neoplastic oral mucosa: keratinocytes positive for CD24 in a fishnet pattern (original magnification ×250); K, Tumor island with a few central neoplastic cells positive for CD24 (original magnification ×250); L, A single cell positive for CD24 in an SCC island (original magnification ×400); M, CD133 expression in non-neoplastic oral mucosa: Note the irregular intensity of the positive fishnet pattern of CD133 (original magnification ×400); N, CD133 expression in the central area of tumor islands (original magnification ×400); O, Strong CD133 expression in neoplastic cells undergoing keratinization (original magnification ×400); P, Ki-67 expression in basal keratinocytes of non-neoplastic oral mucosa (original magnification ×200); Q and R, SCC with a high index of Ki-67 positivity (original magnification ×200 and ×200, respectively).
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology  , DOI: ( /j.oooo )
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3. Fig. 2
Oral cavity squamous cell carcinoma showing neoplastic cells positive for both CD44 (brown staining) and ALDH1 (red staining) co-localized (see arrows) (original magnification ×600).
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology  , DOI: ( /j.oooo )
Copyright © 2016 Elsevier Inc. Terms and Conditions

4. Fig. 3
Cancer-specific survival analysis curve in patients with squamous cell carcinoma of the oral cavity and oropharynx with positive or negative CD44 expression. The 5-year cancer-specific survival rates for patients with positive (red line) and negative (black line) CD44 expression were 38% and 74%, respectively.
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology  , DOI: ( /j.oooo )
Copyright © 2016 Elsevier Inc. Terms and Conditions