1. Pedigree analysis: determining the pattern of inheritance

2. Human Pedigrees
The use of pedigrees is an important method for analyzing the inheritance of traits in human populations

3. Patterns of Inheritance
Six basic patterns
Autosomal dominant
Autosomal recessive
X-linked dominant
X-linked recessive
Y-linked
Mitochondrial inheritance

4. New Computer Software can be used to Prepare Pedigrees

5. Keep In Mind
Pedigree construction and analysis are basic methods in human genetics

6. A Rare Autosomal Recessive Trait

7. Some Autosomal Recessive Traits

8. Pedigree: An Autosomal Dominant Trait

9. Some Autosomal Dominant Traits

10. Example of an Autosomal Dominant Trait
Marfan syndrome
Affects the skeletal system, cardiovascular system, and eyes
Individuals are tall, thin, long arms and legs–thin fingers
Heart defects

11. Cardiovascular Effects of Marfan Syndrome
Aorta
Vena cava
Pulmonary artery
Right auricle
Left ventricle
Right ventricle

12. Cardiovascular Effects of Marfan Syndrome
Aorta
Area of aorta affected in
Marfan
syndrome
Right auricle
Left ventricle
Right ventricle