1. Current status of antibodies (Myositis Profile) in Inflammatory myositis.
Dr Chandrashekara S
Medical Director
ChanRe Rheumatology & Immunology Center and Research

2. Introduction
Idiopathic inflammatory myopathies (IIM) are a group of systemic diseases characterized by an immune mediated attack on skeletal muscle
Characterized by
Proximal muscle weakness
Nonsuppurative inflammation of skeletal muscle
Accompanied by extramuscular manifestations
Arthritis, Skin lesions, ILD, Calcinosis, Nodules and vasculitis

3. Classification of Idiopathic Inflammatory Myopathy
Dermatomyositis
Juvenile
Adult
Polymyositis
T cell mediated
Eosinophilic
Granulomatous
Inclusion body myositis
Overlap Syndrome
Antisynthetase syndrome
Cancer associated myositis

4. What is the role of these AA Epiphenomena or pathognomonic?

5. Where do we stand

15. Prognosis- yes

17. How do we use it Ms X Muscle weakness from 3 month Joint pains
Elevated SGPT/ OT normal GGT
Elevated CPK
ANA –ve
Biopsy patient refusing

18. Case Ctd…
Myositis profile
Shows positive Jo 1 +++

19. Case Ctd… Evaluation for ILD Management plans
Regular follow up for ILD

20. Myositis profile
Mi -2
Myositis specific antibodies are useful in diagnosis and therapeutic management of poly/dermatomyositis.
Anti Mi-2 is highly specific for dermatomyositis, found in 15-30%
PM-Scl in 50-70% of overlap syndromes with SSc
Jo-1 : prevalance is 25-55%. Associated with interstitial lung fibrosis.
PL-7 & Pl-3 : prevalance is 3-6% and 3% respectively. Ku
Jo-1
PL-12
PL-7
Ro-52
PM-Scl
control

21. Thank you….