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Trastuzumab emtansine associated nodular regenerative hyperplasia: A case report and review of literature  L.H. Prochaska, I. Damjanov, R.M. Ash, J.C.

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Presentation on theme: "Trastuzumab emtansine associated nodular regenerative hyperplasia: A case report and review of literature  L.H. Prochaska, I. Damjanov, R.M. Ash, J.C."— Presentation transcript:

1 Trastuzumab emtansine associated nodular regenerative hyperplasia: A case report and review of literature  L.H. Prochaska, I. Damjanov, R.M. Ash, J.C. Olson, Q.J. Khan, P. Sharma  Cancer Treatment and Research Communications  Volume 5, Pages (January 2016) DOI: /j.ctrc Copyright © 2015 Elsevier Ltd Terms and Conditions

2 Fig. 1 CT imaging changes following T-DM1 initiation.
Cancer Treatment and Research Communications 2016 5, 26-30DOI: ( /j.ctrc ) Copyright © 2015 Elsevier Ltd Terms and Conditions

3 Fig. 2 Liver function tests (A) and platelet levels (B) in relation to T-DM1 initiation and discontinuation. Cancer Treatment and Research Communications 2016 5, 26-30DOI: ( /j.ctrc ) Copyright © 2015 Elsevier Ltd Terms and Conditions

4 Fig. 3 Nodular regenerative hyperplasia (A) Hepatocytes form indistinct small nodules (arrows) compressing the surrounding cells. H&E×160. (B) Reticulin stain outlines the nodules and the compressed hepatocytes around them (×160). (C) Immunohistochemical stain with antibodies to cytokeratin that stains selectively the bile ducts and ductules. The lower lobule shows a ductal reaction around a portal tract missing the primary duct (bottom part of the figure). In the upper lobule there is a “blush-like” staining of periportal hepatocytes undergoing ductal metaplasia (×220). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.) Cancer Treatment and Research Communications 2016 5, 26-30DOI: ( /j.ctrc ) Copyright © 2015 Elsevier Ltd Terms and Conditions

5 Fig. 4 Treatment history timeline leading to development of NRH.
Cancer Treatment and Research Communications 2016 5, 26-30DOI: ( /j.ctrc ) Copyright © 2015 Elsevier Ltd Terms and Conditions


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