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Expression of mutant human P5C dehydrogenase alleles in yeast

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Presentation on theme: "Expression of mutant human P5C dehydrogenase alleles in yeast"— Presentation transcript:

1 Expression of mutant human P5C dehydrogenase alleles in yeast
Expression of mutant human P5C dehydrogenase alleles in yeast. A, A comparison of the growth of yeast strains expressing the indicated mutant P5C dehydrogenase alleles (HV7-9) with strains expressing vector alone (HV1), PUT2 (HV2), the yeast ortholog of P5C dehydrogenase or wild-type human P5C dehydrogenase (HV3, pHsP5CDhS2) on medium with either ammonium sulfate or proline as sole nitrogen source. B, The P5C dehydrogenase activity of extracts of these strains. Source: Disorders of Proline and Hydroxyproline Metabolism, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: November 14, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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