1. The 3-compartment pharmacokinetic model
The 3-compartment pharmacokinetic model. The terms in the exponential equation (Figure 1–6) are rearranged as compartment volumes and rate constants between compartments. A 3-compartment model is used to describe an exponential equation with 3 terms. Rate constants are converted into clearance rates. Compartment volumes and clearances are used to generate predictions of drug concentration for various dosing regimens. IV, intravenous.
Source: Pharmacokinetics, Biophase, and Pharmacodynamics and the Importance of Simulation, Clinical Pharmacology for Anesthesiology
Citation: Johnson KB. Clinical Pharmacology for Anesthesiology; 2015 Available at: Accessed: November 14, 2017
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