Presentation is loading. Please wait.

Presentation is loading. Please wait.

Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm.

Published byAldous Jefferson Modified over 6 years ago

Similar presentations

Presentation on theme: "Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm."— Presentation transcript:

1 Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm in Marfan syndrome  H.H. Clarice Yang, MSc, Jong Moo Kim, BSc, Elliott Chum, MD, Cornelis van Breemen, PhD, DVM, Ada W.Y. Chung, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 140, Issue 2, Pages e2 (August 2010) DOI: /j.jtcvs Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Average diameter thoracic aorta. A, Ascending; B, descending. Hatch mark indicates P < .05 versus age-matched control. Asterisk indicates P < .05 versus age-matched untreated Marfan group. LOR, Losartan potassium; DOX, doxycycline. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 A, Averaged architecture score of aortic wall (n = 7–10). Three aortic segments from each mouse (9 months) were examined by 3 observers blinded to genotype and treatment. B, Breaking stress of thoracic aorta. Hatch mark indicates P < .05 versus age-matched control. Asterisk indicates P < .05 versus age-matched untreated Marfan group. LOR, Losartan potassium; DOX, doxycycline. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Integrity of elastic fibers examined on Movat-stained cross-sections of ascending thoracic aorta (ATA), arch, and descending thoracic aorta (DTA) from control, Marfan, Marfan with losartan potassium (LOR), Marfan with doxycycline (DOX), and Marfan with both drugs at 9 months. Elastic fibers are stained as black fibrils. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 A, Representative gelatinolytic zymograms indicating activities of matrix metalloproteinases (MMPs) 2 and 9. B, Representative Western blots showing protein expressions of matrix metalloproteinases 9 and 2, tissue inhibitors of metalloproteinase (TIMPs) 1 and 2, transforming growth factor β (TGF-β), and phosphorylated Smad2 (p-Smad2) in aortic samples. Densitometric analysis shows ratios of expressions of matrix metalloproteinase 9/tissue inhibitor of metalloproteinase 1 (C) and matrix metalloproteinase 2/tissue inhibitor of metalloproteinase 2 (D). Asterisk indicates P < .05 versus age-matched untreated Marfan group. LOR, Losartan potassium; DOX, doxycycline. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

6 Figure 5 Contraction induced by 60-mmol/L potassium chloride (KCl, A and B). A, At 6 months; B, at 9 months. Contraction stimulated by phenylephrine (PE) at 9 months of age (C and D). C, Maximal response (Emax); D, Negative logarithm of 50% effective concentration (pEC50). Maximal relaxation induced by acetylcholine (ACh, E and F). E, At 6 months; F, at 9 months. Asterisk indicates P < .05 versus age-matched untreated Marfan group. LOR, Losartan potassium; DOX, doxycycline. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Download ppt "Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm."

Similar presentations

Resection of ascending aortic aneurysm without use of an interposition aortic graft John S. Ikonomidis, MD, PhD, FRCS(C), Abe DeAnda, MD, D.Craig Miller,

Resection of ascending aortic aneurysm without use of an interposition aortic graft John S. Ikonomidis, MD, PhD, FRCS(C), Abe DeAnda, MD, D.Craig Miller,
Manuel J. Antunes, MD, PhD, DSc 

Manuel J. Antunes, MD, PhD, DSc 
Aortic valve replacement in low-flow, low-gradient aortic stenosis: Left ventricular ejection fraction matters  Victor Dayan, MD, PhD, Philippe Pibarot,

Aortic valve replacement in low-flow, low-gradient aortic stenosis: Left ventricular ejection fraction matters  Victor Dayan, MD, PhD, Philippe Pibarot,
Giant thrombus in ascending aorta and aortic arch

Giant thrombus in ascending aorta and aortic arch
Recent advances in understanding Marfan syndrome: Should we now treat surgical patients with losartan?  Peter Matt, MD, Jennifer Habashi, MD, Thierry.

Recent advances in understanding Marfan syndrome: Should we now treat surgical patients with losartan?  Peter Matt, MD, Jennifer Habashi, MD, Thierry.
Response of plasma matrix metalloproteinases and tissue inhibitor of metalloproteinases to stent-graft surgery for descending thoracic aortic aneurysms 

Response of plasma matrix metalloproteinases and tissue inhibitor of metalloproteinases to stent-graft surgery for descending thoracic aortic aneurysms 
Dysregulated gene expression of extracellular matrix and adhesion molecules in saphenous vein conduits of hemodialysis patients  Yongxin Sun, MD, Wenjun.

Dysregulated gene expression of extracellular matrix and adhesion molecules in saphenous vein conduits of hemodialysis patients  Yongxin Sun, MD, Wenjun.
Wanfen Xiong, PhD, Rebecca A. Knispel, BS, Harry C

Wanfen Xiong, PhD, Rebecca A. Knispel, BS, Harry C
Pressure distention compared with pharmacologic relaxation in vein grafting upregulates matrix metalloproteinase-2 and -9  Ada W.Y. Chung, PhD, Pooja.

Pressure distention compared with pharmacologic relaxation in vein grafting upregulates matrix metalloproteinase-2 and -9  Ada W.Y. Chung, PhD, Pooja.
Gorav Ailawadi, MD, Christopher W. Moehle, BS, Hong Pei, MD, Sandra P

Gorav Ailawadi, MD, Christopher W. Moehle, BS, Hong Pei, MD, Sandra P
Differential expression of elastin assembly genes in patients with Stanford Type A aortic dissection using microarray analysis  Bernice L.Y. Cheuk, PhD,

Differential expression of elastin assembly genes in patients with Stanford Type A aortic dissection using microarray analysis  Bernice L.Y. Cheuk, PhD,
Pioglitazone preserves vein graft integrity in a rat aortic interposition model  Zhi Chen, MD, Tomomi Hasegawa, MD, PhD, Akiko Tanaka, MD, Yutaka Okita,

Pioglitazone preserves vein graft integrity in a rat aortic interposition model  Zhi Chen, MD, Tomomi Hasegawa, MD, PhD, Akiko Tanaka, MD, Yutaka Okita,
Jennifer Chung, MD, MSc, Maral Ouzounian, MD, PhD 

Jennifer Chung, MD, MSc, Maral Ouzounian, MD, PhD 
New ascending aortic aneurysm model in rats reproduces main structural features of degenerative ascending thoracic aortic aneurysms in human beings  Narcis.

New ascending aortic aneurysm model in rats reproduces main structural features of degenerative ascending thoracic aortic aneurysms in human beings  Narcis.
Amine Mazine, MD, MSc, Subodh Verma, MD, PhD, Bobby Yanagawa, MD, PhD 

Amine Mazine, MD, MSc, Subodh Verma, MD, PhD, Bobby Yanagawa, MD, PhD 
Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: Role of Smad1 and extracellular signal-regulated.

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: Role of Smad1 and extracellular signal-regulated.
Murray H. Kwon, MD  The Journal of Thoracic and Cardiovascular Surgery 

Murray H. Kwon, MD  The Journal of Thoracic and Cardiovascular Surgery 
Intrinsic cardiac stem cells are essential for regeneration

Intrinsic cardiac stem cells are essential for regeneration
Induction of human aortic myofibroblast-mediated extracellular matrix dysregulation: A potential mechanism of fluoroquinolone-associated aortopathy  David.

Induction of human aortic myofibroblast-mediated extracellular matrix dysregulation: A potential mechanism of fluoroquinolone-associated aortopathy  David.
Elevated messenger RNA expression and plasma protein levels of osteopontin and matrix metalloproteinase types 2 and 9 in patients with ascending aortic.

Elevated messenger RNA expression and plasma protein levels of osteopontin and matrix metalloproteinase types 2 and 9 in patients with ascending aortic.

Similar presentations

Ads by Google