1. Post-mitotic pool (6.5 days)
Myeloblast
(~10 m; ~2%)
Promyelocyte
(~15 m; ~5%)
Myelocyte
(~10 m; ~12%)
Mature PMN
(~8-12 m; ~20%)
Band cell
(~8-12 m; ~11%)
Metamyelocyte
(~8-12 m; ~10%)
Post-mitotic pool (6.5 days)

2. Fusion with plasma membrane
Heparanase release
Gelatinase release
Increased cell surface expression of CD11b/CD18
Cyt. b558  oxygen metabolites
Exocytosis
Fusion with plasma membrane
Gelatinase
Heparanase
CD11b/CD18
Cytochrome b558
Vacuolar H+-ATPase
(Adhesion to endothelium and diapedesis)
Tertiary granule
Phagocytosis
Cyt. b558  H2O2
Vacuolar H+-ATPase  acid pH
Fusion with phagocytic vacuoles
(Potentiation of antimicrobial activity)

3. Simple exocytosis
Compound exocytosis
Cumulative fusion

4. Specific and tertiary granules
Plasma membrane
SNAP-23
VAMP-2
Specific and tertiary granules
Syntaxin 4
Syntaxin 6