1. 2141350 Biological Interactions with Materials
Instructors: Dr. Niti Yongvanich, PhD course coordinator
Dr. Pimpon Uttayarat, PhD
Textbook: Biomaterials Science: an introduction to materials in medicine/ edited by Buddy D. Ratner, 1st or 2nd Edition, Elsevier.
Supplement Reading: Selected journal paper
Grading: Dr. Niti Yongvanich 60%
Dr. Pimpon Uttayarat 40% (HW 10%, Exam 25%, Part 5%)
Contact:

2. Outline Date Topics 1/8/20011 Introduction
1/15/ Proteins, Cells and Tissues
1/22/ Host reactions to biomaterials
1/29/ Testing materials
2/5/ Polymers as biomaterials
(cardiovascular prostheses, burn dressings)
2/12/ Introduction and properties of materials
2/19/ Introduction to practical aspects of biomaterials
2/26/ Midterm

3. Date Topics 3/5/2011 Introduction to practical aspects of biomaterials
3/12/ Implants, devices, and biomaterials: Issues unique to this field
3/19/ Implants, devices, and biomaterials: Issues unique to this field
3/26/ New products and standards. Perspectives and
possibilities in Biomaterials Science
4/2/ New products and standards. Perspectives and
4/9/ TBA
4/16/ Presentation

4. Important definitions
A biomaterial is a nonviable material used in a medical device, intended to interact with biological systems. (David Williams, 1987)
biocompatibility: the ability of a material to perform with an appropriate host response in a specific application in the way that it does not provoke rejection by the body
to replace/restore the function of the diseased or damaged tissue
to facilitate the healing with surrounding host tissue
biomaterials include synthetic and natural materials

5. Table 1 Some applications of synthetic materials and modified natural materials in medicine
Biomaterials Science p.3

6. Autograft is a tissue transplanted from one part of the body to another in the same individual.
Allograft is an organ or tissue transplanted from one individual to another of the same species but different genotype.
Xenograft is an organ or tissue taken from one species to an unlike species.
Tissue Engineering is an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function or a whole organ. (Langer and Vacanti 1993)
therapeutic application or diagnosis application
include the following areas: biomaterials, cells, biomolecules, engineering design, biomechanical aspect of the design and informatics
Regenerative medicine is interchangeably used with tissue engineering but strictly speaking the term primarily involves the use of stem cells to restore the tissue/organ function.

7. Useful resource: www.ncbi.nlm.nih.gov

8. Example: search pubmed for fibronectin adsorption

9. Example: search pubmed for a paper when you know the journal title, volume and year
Garcίa et al., Mol Biol Cell, 10, , 1999.

10. Garcίa et al., Mol Biol Cell, 10, 785-798, 1999.

11. Homework due 1/15/11
Use pubmed to find a journal paper on fibronectin/collagen/vitronectin adsorption. Write a short paragraph summarizing the abstract.
The summary must include:
Title of the paper
The name of the first author
The name of journal, volume and date of publication
The objective of the paper/experiment (1-2 sentences)
The main finding of the paper (2-4 sentences)
Indicate if there’s a full text link to the paper

12. Part II: Materials in Medicine
Biomaterials Science
Part II: Materials in Medicine
Proteins, Cells and Tissues Jan 15, 2011
textbook
Biomaterials Science: An Interdisciplinary Endeavor
Chapter 3