1. Funding Clinical Research A Superficial Guide for the Neophyte
JOHNS HOPKINS HOSPITAL IN THREE CENTURIES
Jeff Brinker MD, FACC, FSCAI
Professor of Medicine and Radiology
Johns Hopkins University

2. I/we have no real or apparent conflicts of interest to report.
Jeff A. Brinker, MD
I/we have no real or apparent conflicts of interest to report.

3. THINGS TO CONSIDER What are my short and long term goals?
What are my primary research interests?
What kind of research do I want to do?
Do I actually need money to do the research?
Would I rather perform an intervention than write a grant?
Grants are competitive, demonstration of research ability and peer reviewed publications are helpful.
Have a good mentor and rely on him/her

4. Life Science Research in U.S. Academic Medical Centers
Among AMC research faculty, 33.6% exclusively conducted basic science research as principal investigators compared with translational researchers (9.1%), clinical trial investigators (7.1%), and health services researchers/clinical epidemiologists(9.0%). While principal investigators garnered a mean of $ in total annual research funding, 22.1% of all AMC research faculty were unsponsored, a proportion that ranged from 11.5% for basic science researchers to 46.8% for health services researchers (P.001). The average AMC faculty member received $ in industrysponsored funding, with most of this money concentrated among clinical trial ($ ) and multimode ($59 916) principal investigators. Translational (61.3%), clinical trial(67.3%), and multimode (70.9%) researchers were significantly more likely than basic science researchers (41.9%) to report a relationship with industry and that these relationships contributed to their most important scientific work (P.05 for all comparisons).
Zinner and Campbell. JAMA. 2009;302(9):

5. WHY SHOULD YOU APPLY FOR A GOVERNMENT GRANT?
Response when he was asked why he only robbed banks!

6. THE INTERNET
A KEY RESOURSE FOR IDENTIFYING OPPORTUNITIES, APPLYING FOR, AND SUBMITTING GRANTS

7. How Do I Get Funded? Government Industry
Private Foundations & Voluntary
Health Associations
AMC

8. WHO PAYS FOR
HEALTH
RESEARCH?

10. Private Foundation

11. National Football League

12. Voluntary Health Associations

13. State Funding of Medical Research

14. Grant Providing Federal Government Agencies
Agency for International Development
Corporation for National and Community Service
Department of Agriculture
Department of Commerce
Department of Defense
Department of Education
Department of Energy
Department of Health and Human Services
Department of Homeland Security
Department of Housing and Urban Development
Department of the Interior
Department of Transportation
Department of Justice
Department of labor
Department of State
Department of the Treasury
Department of Veteran Affairs
Environmental Protection Agency
Institute of Museum and Library Services
NASA
National Archives and Records Administration
National Endowment of the Arts
National Endowment for the Humanities
National Science Foundation
Small Business Administration
Social Security Administration

15. The VA

16. Department of Defense

17. Centers for Medicare & Medicaid Services
Grants to Improve:
1. QUALITY OF CARE
ACCESSABILITY OF CARE
OFFER JOBS
MORE EFFICENT CARE

18. NIH GRANTS AND FUNDING

20. Center
for
Scientific
Review

22. Categories of NIH Funding

23. Applying to eRA Commons (Electronic Research Administration)
Applications must be submitted in response to a funding opportunity announcement (FOA. Request for applications (RFAs) and program announcements (PAs) are types of funding opportunity announcements.
Applicants submitting “investigator initiated” or “unsolicited” applications should use Parent Announcements, which span the breadth of the OER (Office of Extramural Research) mission.

24. The Grant Process

25. The Grant Process Continued

27. ADVICE
Convey the proposal completely and clearly: What you want to do; Why you want to do it; How you are going to do it.
Don’t be overambitious.
Covey the impact of your proposal and how it will move science to a practical (clinical) goal.
Grantsmanship: Reviewers are influenced by the clarity of the proposal, its logic, the quality of the idea, and whether it’s innovative.
The proposal should be reviewed by a mentor and other individuals who have gone through the process.
Participation in a review process yourself (e.g. journal articles, in-house research) will provide you with a helpful perspective in writing a grant.
Persevere, if the grant is rejected pay attention and address criticism brought up in the summary statement.

28. FINAL THOUGHTS Be focused, keep your eye on the prize!
Be unambiguous; don’t be caught between ideas.
There are about 16 applications for every grant funded.