Download presentation
Presentation is loading. Please wait.
1
Glycolysis
2
Overview of glucose metabolism
Pathway Function glycolysis, citric acid cycle, respiratory chain complete degradation of glucose for ATP production hexose monophosphate shunt degradation of glucose for regeneration of NADPH glycogen synthesis and degradation short-term glucose storage gluconeogenesis synthesis of glucose from amino acids, lactate, or acetone
3
The place of glycolysis in glucose degradation
4
Alternate structures of D-glucose
5
Reactions in glycolysis
6
The phosphate groups in ATP are shielded from nucleophilic attack
7
The catalytic mechanism of hexokinase
8
Hexokinase envelopes its substrates to prevent ATP hydrolysis
9
Phosphohexose isomerase performs acid-base catalysis
10
Glyceraldehyde-3-phosphate dehydrogenase carries out covalent catalysis
11
Structure and redox chemistry of NAD+ and NADP+
12
Pyruvate Kinase
13
Energy-rich functional groups in substrates of glycolysis
the enolphosphate in PEP the carboxyphosphate in 1,3-bisphosphoglycerate the thioester in the active site of glyceraldehyde-3-dehydrogenase
14
Regeneration of cytosolic NAD+ under aerobic conditions
15
Under anaerobic conditions, NAD+ is regenerated by lactate dehydrogenase
16
Ethanolic fermentation in yeast serves a dual purpose
17
Kinetics of glucose transport by facilitated diffusion
18
GLUT transporters in different tissues vary in their affinity for glucose
19
Reaction velocities of hexokinase and glucokinase
Similar presentations
© 2024 SlidePlayer.com. Inc.
All rights reserved.