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P. Therasse, S. Carbonnelle, J. Bogaerts 

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Presentation on theme: "P. Therasse, S. Carbonnelle, J. Bogaerts "— Presentation transcript:

1 Clinical trials design and treatment tailoring: General principles applied to breast cancer research 
P. Therasse, S. Carbonnelle, J. Bogaerts  Critical Reviews in Oncology / Hematology  Volume 59, Issue 2, Pages (August 2006) DOI: /j.critrevonc Copyright © Terms and Conditions

2 Fig. 1 Trial design SOFT. Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © Terms and Conditions

3 Fig. 2 Trial design TEXT. Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © Terms and Conditions

4 Fig. 3 Trial design PERCHE.
Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © Terms and Conditions

5 Fig. 4 Trial design to test the overall predictive value of a marker.
Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © Terms and Conditions

6 Fig. 5 Trial design to test if treatment A or B best suits for marker positive/negative patients. Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © Terms and Conditions

7 Fig. 6 Trial design allowing the evaluation of both the treatment and the marker effect. Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © Terms and Conditions

8 Fig. 7 Registration design.
Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © Terms and Conditions

9 Fig. 8 Two-way stratified design.
Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © Terms and Conditions

10 Fig. 9 Classifier randomization design.
Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © Terms and Conditions

11 Fig. 10 Proposed classification matrix for novel molecularly targeted therapies. Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © Terms and Conditions


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