1. Nutrient or ion regulation of hormone release
Nutrient or ion regulation of hormone release. This is the simplest form of control mechanism, where the hormone is directly influenced by the circulating blood levels of the substrate that the hormone itself controls. This sets up a simple control loop in which the substrate is controlling release of the hormone, which by its action(s) is altering the level of the substrate. Examples of this type of control are calcitonin and parathyroid hormone (substrate is calcium), aldosterone (substrate is potassium), and insulin (substrate is glucose). This control mechanism is possible because of the ability of endocrine cells to sense the changes in substrate concentrations. PTH, parathyroid hormone.
Source: Chapter 1. General Principles of Endocrine Physiology, Endocrine Physiology, 4e
Citation: Molina PE. Endocrine Physiology, 4e; 2013 Available at: Accessed: November 14, 2017
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