1. Summary
J.Ochotná

2. The main function of the immune system
Defense
Autotolerance
Immune surveillance

3. Nonspecific immune mechanisms
non-adaptive, congenital
evolutionarily older
respond to the presence of harmful substances quickly
recognize structural features common to many pathogens
absence of immunological memory
components - cellular (phagocytes, NK cells)
- humoral (complement, interferons, lectins and other serum proteins)

4. Specific immune mechanisms
adaptive
evolutionarily younger
antigen specific
Immunological memory
components - humoral (antibody)
- cellular (T lymphocytes)

5. Components of the immune system
lymphoid tissues and organs
cells of the immune system
molecules of the immune system
Lymphoid tissues and organs
primary lymphoid organs (bone marrow, thymus)
secondary lymphoid tissues and organs (spleen, lymph nodes and their organized clusters, MALT)

6. Lymphoid tissues and organs

8. Phagocytosis

9. Mast cell activation

10. Natural killer cell

11. Complement

12. T cell development
T cell development

13. Positive a nd negative selection

14. Antigen specific receptors
TCR
BCR

15. Antigen presentation 15

16. Antigen presentation

17. Peptides binding to MHC gp I17

18. Peptides binding to MHC gp II18

20. T cell activation Signal TCR (T cell) – MHC gp I (II)+Ag peptid (APC)
Signal - costimulatory CD 28 (T cell) – CD 80, CD 86 (APC) 20

22. Th1 and Th2 reaction

24. Cytotoxic T lymphocyte

25. B cell activation

26. Isotype switching

27. Antibody structure

28. Antibody isotypes