1. From: NKT Cell Exacerbation of Liver Metastases Arising from Melanomas Transplanted into Either the Eyes or Spleens of Mice
Invest. Ophthalmol. Vis. Sci ;52(6): doi: /iovs
Figure Legend:
Resistance to liver metastases in NKT-cell–deficient mice was NK-cell dependent and T-cell independent. (A) Liver metastases in mice before and after NK cell depletion. This experiment was performed twice with similar results. n = 5 mice/group/experiment. (B) Liver metastases in SCID mice and in wild-type mice that received an intrasplenic injection of B16LS9 melanoma cells. Results represent pooled results from three independent experiments. (C) Liver NK cell-mediated cytotoxicity in SCID mice and wild-type mice bearing B16LS9 liver metastases induced by intrasplenic melanoma cell injection. The results are pooled from two independent experiments. (D) Number of liver NK cells (DX5+TCR-β −) detected by flow cytometry in mice bearing liver metastases produced by intrasplenic injection of B16LS9 melanoma cells. This experiment was performed twice with similar results (n = 5 mice/group/experiment). **P < Results are expressed as the mean ± SD.
Date of download: 11/14/2017
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