1. Department of Nuclear Medicine, East-West Neo Medical Center,
The Comparison with Salivary image and Saliva Clerance Rate in Salivary Scintigraphy
Department of Nuclear Medicine,
East-West Neo Medical Center,
Kyung Hee University
Kim Young-Bin

2. SALIVARY GLAND • Secretion 1,000 ~ 1,500 cc/day
Digestion of starch & Softening
of food
Moisture conservation of
the membrane’s oral cavity
Prevention of bacteria’s
reproduction.
• Sialolithiasis, xerostomia,
halitosis, Sjogren’s syndrome.

3. SALIVARY EXAM Advantage Disadvantage Noninvasive
Sonography
Noninvasive
Easy detection sialolithiasis
Sialography
No quantification of function
No quantification of obstruction
Easy detection sialolithiasis
CT, MRI
High geometric resolution
Salivary Scan
Quantification of function
Quantification of obstruction
No morphological presentation

4. OBJECT Salivary Diagnosis in Clinic : Static Image & Dynaminc Image
Relationship
Advantage
Previous study
: Salivary clearance rate

5. TARGET 37 patients ( male 9, female 27 ) June 2007 ~ June 2008
halitosis patients
xerostomia patients
radioisotope therapy patients
6hr NPO before testing
Tc-99m pertechnetate 185 MBq (5 mCi ) IV

6. Philips Gamma Camera Forte A-Z
MACHINE
CAPTUS 3000, CAPINTEC
Philips Gamma Camera Forte A-Z

7. After stimulation phase
PROCESS
5 MIN
Concentration phase
15 MIN
Secretory phase
Stimulation
40 MIN
After stimulation phase

8. STIMULATION Saliva & blood collection process flow
12 min
Stimulation [ 2 min]
Saliva collection [ 10 min ]
Stimulate [ 1 min ]
5 min saliva collection
Spit out [ 1 min ]
Thyroid uptake - captus
After 2Hrs
Blood sampling 1cc
Saliva sampling 1cc
5 min - Blood 5 ml extraction
Saliva & blood collection process flow
KYUNG HEE UNIVERSITY
EAST-WEST NEO MEDICAL CENTER

9. METHOD Secretory image count Secretion rate (%) = - 1
Concentration image count
Secretory image count
Drainage rate (%) =
- 1
After stimulation count
Saliva radioactivity (cpm/ml) ×Saliva volume (ml)
Saliva clearance rate(ml/min) =
Blood radioactivity (cpm/ml) ×Saliva gathering time (min)

10. METHOD Normal : Mildly 5 Group 1 : Moderate 17
Group 2 : Severe function of parotid
or submandibular gland
Group 3 : Non function

11. Salivary clearance rate
RESULT
Salivary clearance rate
(ml/min)
patient

12. RESULT
Secretion rate
(%)
patient

13. RESULT
Drainage rate
(%)
patient

14. Saliva clearance rate (ml/min)
RESULT
Normal
Group 1
Group 2
Group 3
Saliva clearance rate (ml/min)
18.4
16.1
10.0
2.3
Secretion rate (%)
21.6
17.6
8.8
4.4
Drainage rate (%)
24.6
24.0
13.9
5.8
Group 2 & p < Significant difference
Group p > Insignificant difference
Saliva clearance rate
Group 2 & p < Significant difference
Group p > Insignificant difference
Secretion & Drainage rate

15. CONCLUSION Salivary clearance rate increade Salivary image
Saliva Clearance rate
Nonfunction patient decrease
Secretion & Drainage rate increase
Accordance
Salivary images
Saliva clearance rate
Severe function of Pa. or Su.
Abnormal secretion & Drainage velocity
Noticeable difference
Make up for error

16. Department of Nuclear Medicine, East-West Neo Medical Center,
Thank You ♡
Department of Nuclear Medicine,
East-West Neo Medical Center,
Kyung Hee University