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Clinical Prediction Model To Characterize Pulmonary Nodules
Herder Gerarda J. , MD, van Tinteren Harm , MSc, Golding Richard P. , MD, Kostense Piet J. , PhD, Comans Emile F. , PhD, Smit Egbert F. , PhD, Hoekstra Otto S. , PhD CHEST Volume 128, Issue 4, Pages (October 2005) DOI: /chest Copyright © 2005 The American College of Chest Physicians Terms and Conditions
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Figure 1 Validation of the clinical prediction model of Swensen in 106 patients with SPNs. Dxy = Somers Dxy rank correlation between actual and predicted probability; C = ROC area; R2 = Nagelkerke-Cox-Snell-Maddala-Magee R2 index; D = discrimination index (logistic model LR-χ2-1/n); U = unreliability index (χ2 with 2 degrees of freedom for testing unreliability); Q = quality index Q, Brier score (ie, the average squared difference between actual and predicted probability); Emax = maximum absolute difference in predicted and calibrated probabilities. CHEST , DOI: ( /chest ) Copyright © 2005 The American College of Chest Physicians Terms and Conditions
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Figure 2 ROC curves for the prediction model of Swensen et al2 and for a model combining Swensen pretest probability with FDG-PET scan results. Swensen = logistic probability model of Swensen et al2 FDG-PET (4 categories) = FDG-PET scan result in four categories (ie, no uptake, faint, moderate, and intense); Swensen + PET = the logistic model combined with PET scan information. CHEST , DOI: ( /chest ) Copyright © 2005 The American College of Chest Physicians Terms and Conditions
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Figure 3 Nomogram using information from the clinical prediction model and FDG-PET scan. The probability of malignancy based on the model of Swensen et al2 and the FDG-PET scan result are indicated in the nomogram. First, the patient's position on each predictor variable scale is defined. Each scale position has corresponding prognostic points located on the points scale at the top. These two numbers are then summed to arrive at a total points value on the total points axis. A vertical line is then drawn from the total points axis down to the probability to indicate the probability of malignancy. CHEST , DOI: ( /chest ) Copyright © 2005 The American College of Chest Physicians Terms and Conditions
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Figure 4 Bootstrap calibration curve of the clinical prediction model of Swensen et al2 with the FDG-PET scan result (four categories) in 106 patients with SPNs. CHEST , DOI: ( /chest ) Copyright © 2005 The American College of Chest Physicians Terms and Conditions
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