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Figure 1. Chemical structures of paeoniflorin and hyperoside.
From: Determination of Paeoniflorin in Rat Plasma by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study J Chromatogr Sci. 2017;55(10): doi: /chromsci/bmx066 J Chromatogr Sci | © Crown copyright 2017.This article contains public sector information licensed under the Open Government Licence v3.0 (
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Figure 2. Full-scan product ion mass spectra of [M + HCOOH-H]<sup>−</sup> ion and fragmentation pathway for paeoniflorin (A) and [M-H]<sup>−</sup> ion for hyperoside (B). From: Determination of Paeoniflorin in Rat Plasma by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study J Chromatogr Sci. 2017;55(10): doi: /chromsci/bmx066 J Chromatogr Sci | © Crown copyright 2017.This article contains public sector information licensed under the Open Government Licence v3.0 (
![Figure 2. Full-scan product ion mass spectra of [M + HCOOH-H]<sup>−</sup> ion and fragmentation pathway for paeoniflorin (A) and [M-H]<sup>−</sup> ion for hyperoside (B).](http://slideplayer.com./slide/13611663/83/images/2/Figure+2.+Full-scan+product+ion+mass+spectra+of+%5BM+%2B+HCOOH-H%5D%3Csup%3E%E2%88%92%3C%2Fsup%3E+ion+and+fragmentation+pathway+for+paeoniflorin+%28A%29+and+%5BM-H%5D%3Csup%3E%E2%88%92%3C%2Fsup%3E+ion+for+hyperoside+%28B%29..jpg "From: Determination of Paeoniflorin in Rat Plasma by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study. J Chromatogr Sci. 2017;55(10): doi: /chromsci/bmx066. J Chromatogr Sci | © Crown copyright 2017.This article contains public sector information licensed under the Open Government Licence v3.0 (")
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Figure 3. Chromatograms of paeoniflorin and IS
Figure 3. Chromatograms of paeoniflorin and IS. Top, a blank rat plasma sample; middle, a blank plasma spiked with paeoniflorin (1.6 μg/mL) and IS (1.98 μg/mL); bottom, a rat plasma sample after an oral administration of BC (0.675 g/kg) at intervals of 2 h. From: Determination of Paeoniflorin in Rat Plasma by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study J Chromatogr Sci. 2017;55(10): doi: /chromsci/bmx066 J Chromatogr Sci | © Crown copyright 2017.This article contains public sector information licensed under the Open Government Licence v3.0 (
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Figure 4. Plasma concentration–time profile of paeoniflorin after an oral administration of g/kg BC in rats (n = 8). From: Determination of Paeoniflorin in Rat Plasma by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study J Chromatogr Sci. 2017;55(10): doi: /chromsci/bmx066 J Chromatogr Sci | © Crown copyright 2017.This article contains public sector information licensed under the Open Government Licence v3.0 (
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