1. 學生：李明真 指導教授：陳澄河 教授 日期：2015/12/15
氧化鋰作為SDC 電解質燒結助劑的可行性和機制

2. Outline
Experimental
Results and discussion 1

3. Outline
Experimental 2

4. Introduction(1/3)
1.Hydroxypropylcellulose (HPC) is a kind of hydroxyl-substituted cellulose derivatives and has been used in pharmaceutical,
adhesives, food, cosmetic and controlled drug release.
Nowadays, its thermo-sensitive property has caused
scientists' interest.
2. The dipole moment of the propylene oxide moieties may be decreased in water and the hydrophobic interaction of HPC is so strong that the phase separation of HPC aqueous solution occurs.
HPC
(羥丙基纖維素) 3

5. Introduction(2/3)
3.Interpolymer hydrogen bonding between HPC and PAA led to a dramatic decrease of phase transition .More interestingly, with the help of hydrogen bonding interaction between AA, PAA and HPC, HPC chains dehydrated to form nanocolloids around room temperature and then PAA chains attached on the surface of HPC nanocolloids collapsed to form PAA nanogels, in which HPC acted as a template for the formation of nanogels. 4

6. Introduction(3/3)
4.Herein, using HPC as a template in the absence of surfactant, we synthesized HPC/PMAA nanogels which were dual-responsive to pH and temperature owing to the interpolymer hydrogen bonding between HPC and PMAA, and the influence of polymerization temperature, crosslinker concentration, and HPC concentration to effect size and size distribution of dual-responsive nanogels were systematically studied.
PMAA
(聚甲基丙烯酸) 5

7. Outline
Introduction
Experimental
Results and discussion
Conclusions 6

8. Experimental -Materials
Hydroxypropylcellulose (HPC) powders (average Mw = 1.0 × 105 )
Methacrylic acid monomers (MAA, 99%)
N , N′-methylenebisacrylamide (BIS, crosslinker, 99%) 7

9. Experimental -Materials Ammonium persulfate (APS, 99%, initiator)
N , N , N′, N′-tetramethylethylenediamine (TEMED)
Sodium hydroxide (NaOH) 8

10. 0.1 g crosslinking agent BIS
Experimental
-Aqueous synthesis of nanogels
1 wt.% HPC (aq) 20g
dissolving HPC powder in deionized water under gentle stirring for one week at room temperature
0.3 g MAA
0.1 g crosslinking agent BIS
0.1 g APS
dissolved in 79.4 g DI water under stirring for 60 min to make a homogenous solution.
HPC nanogels 9

11. Experimental The HPC/MAA solution 0.05 g TEMED
purged with nitrogen for 40 min and heated up to 30 °C ,stabilizing for 20 min.
0.05 g TEMED
initiate polymerization and crosslinking to proceed for 60 min
Nanogels were dialyzed for 3 days
remove the unreacted MAA, BIS, and TEMED
deprotonated to pH = 6.5 ± 0.1 by NaOH
DLS
UV–Vis spectrophotometer
FTIR
TEM
AFM 10

12. Experimental 11

13. Outline Introduction Experimental Results and discussion Conclusions12

14. Results and discussion13

15. Results and discussion14

16. Results and discussion15

17. Results and discussion16

18. Results and discussion17

19. Results and discussion
PMAA
(聚甲基丙烯酸) 18

20. Results and discussion19

21. Outline Introduction Experimental Results and discussion Conclusions20

22. Conclusions(1/2)
1.Dual-responsive HPC nanogels have been synthesized using HPC as a template in surfactant-free aqueous media. 2.It was found that the average size of HPC nanogels changed little with increasing polymerization temperature below 26 °C, whereas it greatly increased above 26 °C. 3.When the concentration of HPC was increased from 0.1 to 0.9 wt.%, the diameter of nanogels decreased firstly and then increased. 21

23. Conclusions(2/2)
4.Besides, an increasing crosslinker BIS concentration led to a reduced size of HPC nanogels, and the nanogels had the narrowest size distribution when its concentration was 0.1 wt.%. It was demonstrated that nanogels were both thermo sensitive and pH sensitive due to the coexistence of HPC and PMAA. 5.This green method to prepare HPC nanogels in aqueous solution without surfactant can effectively prevent organic solvent from polymerization system. Dual-responsive HPC nanogels are promised to be used in the field of drug delivery and other nanobiomaterials. 22

24. Thank you for your attention