1. European Urology Focus
A Prospective Observational Study for Assessment and Outcome Association of Circulating Endothelial Cells in Clear Cell Renal Cell Carcinoma Patients Who Show Initial Benefit from First-line Treatment. The CIRCLES (CIRCuLating Endothelial cellS) Study (SOGUG-CEC ) 
Jesús García-Donas, Luis Angel Leon, Emilio. Esteban, Maria Jose Vidal-Mendez, Jose Angel Arranz, Xavier Garcia del Muro, Laura Basterretxea, Aranzazu González del Alba, Miguel Angel Climent, Juan Antonio Virizuela, Carlos Álvarez, Juan Sepúlveda, Urbano Anido, Carlos López, Maria Jose Ortiz-Morales, Xavier. Pérez, Cristina Rodriguez-Antona, Juan Francisco Rodriguez-Moreno, Susana Hernando, Daniel Castellano 
European Urology Focus 
DOI: /j.euf
Copyright © 2016 European Association of Urology Terms and Conditions

2. Fig. 1
Progression-free survival (PFS) assessment. (A) PFS for the study population, (B) baseline circulating endothelial cell (CEC) levels and PFS, and (C) PFS for the study population separated by baseline CEC levels.
CI=confidence interval; HR=hazard ratio.
European Urology Focus DOI: ( /j.euf )
Copyright © 2016 European Association of Urology Terms and Conditions

3. Fig. 2
Graphical representation of hazard ratios of prognostic variables.
CI=confidence interval; MSKCC=Memorial Sloan Kettering Cancer Center.
European Urology Focus DOI: ( /j.euf )
Copyright © 2016 European Association of Urology Terms and Conditions

4. Fig. 3
Circulating endothelial cell (CEC) levels at baseline compared with CEC levels at tumor progression in patients who experienced disease progression during the study.
European Urology Focus DOI: ( /j.euf )
Copyright © 2016 European Association of Urology Terms and Conditions

5. European Urology Focus DOI: (10.1016/j.euf.2016.09.004)
Copyright © 2016 European Association of Urology Terms and Conditions

6. European Urology Focus DOI: (10.1016/j.euf.2016.09.004)
Copyright © 2016 European Association of Urology Terms and Conditions