1. The Chemistry of the Nucleic Acids University of California,
Chapter 26
The Chemistry of the Nucleic Acids
Paula Yurkanis Bruice
University of California,
Santa Barbara

2. RNA and DNA are Phosphodiesters

3. The Bases

4. Nucleosides

5. Nomenclature

6. Mono-, Di-, and Triphosphates

7. Cyclic AMP

8. Biosynthesis of Nucleic Acids

9. Primary Structure

10. Complementary Base Pairing

11. Hydrogen Bonding Dictates Base Pairing

12. DNA

13. Why DNA Does Not Have a 2’-OH Group

14. DNA is Double Stranded

15. Replication

17. Transcription

18. Transcription

19. Transfer RNA

20. Putting the Amino Acid on tRNA

21. An Aminoacyl-tRNA Synthetase

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23. © 2014 Pearson Education, Inc.

24.
© 2014 Pearson Education, Inc.

25. Antiviral Drugs
Most antiviral drugs interfere with the virus’s nucleic acid synthesis.

26. Why does DNA contain thymine instead of uracil?
The synthesis of thymine is energetically expensive

27. Why does DNA contain thymine instead of uracil?
Because cytosine can be converted to uracil ….
Having T’s in place of U’s in DNA allows the U’s that are
found in DNA to be recognized as mistakes