1. CZ5226: Advanced Bioinformatics Lecture 3: MHC Molecules Prof
CZ5226: Advanced Bioinformatics Lecture 3: MHC Molecules Prof. Chen Yu Zong Tel: Room 07-24, level 7, SOC1, National University of Singapore

2. MHC in Immune System

3. MHC in Immune System

4. MHC in Immune System

5. MHC in Immune System

6. MHC in Immune System

7. MHC in Immune System

8. T-Cell Recognition of Peptide Antigen through MHC-peptide complex

9. T-Cell Recognition of Allogeneic MHC

10. Classes of MHC

12. Antigen capture and display

13. Antigen capture and display

14. Cross Presentation of Antigens

15. MHC Genes

16. MHC Genes

17. MHC Genes

18. Properties of MHC genes

19. Properties of MHC genes

20. Properties of MHC Genes

21. Properties of MHC Genes

22. Properties of MHC Genes

23. Structure of MHC

24. MHC Gene and Protein Structure

25. MHC protein structure

26. MHC protein structure

27. Peptide Binding to MHC

28. Peptide Binding to MHC

29. MHC-peptide structure

30. MHC-peptide structure

31. Peptide Binding to MHC

32. Peptide Binding to MHC

33. Peptide Binding to MHC

34. Peptide Binding to MHC

35. Peptide Binding to MHC

37. MHC and Diseases

38. MHC and Diseases

39. Summary of MHC
MHC-I consist of an alpha chain and beta-2 microglobulin and present endogenous peptides to T lymphocytes, which are processed by the cytosolic pathway in APC.
MHC-II have alpha and beta chains and present to T cells exogenous peptides processed by the endocytic pathway.
Non-classical MHC are involved in antigen processing, presentation and tolerance induction.
Minor H antigens are genetic variants of peptides presented by MHC to T cells and cause graft rejection and graft versus host reaction.
HLA has an association with autoimmune disease due to its capacity of altering antigen presentation and clearance, lympocyte activation and tolerance induction.

40. Summary of Today’s lecture
Adaptive immune system
Comparison between innate and adaptive immune system
Relevant cells and related molecules