1. Although – Even though Despite – In spite of
All these words are used to say something that is surprising, unexpected.
Situation: John studied Math very hard, but he failed the test.
Although John studied Math very hard, he failed the test.
Even though John studied Math very hard, he failed the test.
Despite studying Math very hard, he failed the test.
In spite of studying Math very hard, he failed the test.

2. Situation: It was raining heavily, but we finished the football match.
Although it was raining heavily, we finished the football match.
Even though it was raining heavily, we finished the football match.
Despite heavy rain, we finished the football match.
In spite of heavy rain, we finished the football match.

3. When do we use “Although – Even though”
When do we use “Although – Even though”? When do we use “Despite – In spite of”?
even though, although Clause (subject + verb)
despite ,in spite of Noun -- Verb+ing

4. I still enjoyed the picnic despite the weather. (Noun)
He failed the test in spite of studying hard. (Verb + ing)
I like my apartment a lot although it is quite small. (subject + verb)
Even though I got up early, I couldn't catch the bus. (subject + verb)
MORE SENTENCES
He managed to escape even though four men tried to catch him
Despite losing key players to injury, the team won.
He managed to escape although four men tried to catch him
In spite of last night's terrorist attack, most people seem to be going about their business as if nothing had happened