1. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Abstract #182373<br />A Phase II Prospective Study of Selumetinib in Children with Recurrent or Refractory Low-grade Glioma (LGG): A Pediatric Brain Tumor Consortium (PBTC) Study
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

2. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Overview
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

3. Pediatric Low Grade Glioma (LGG)
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

4. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
LGG and MAPK/BRAF
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

5. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Slide 5
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

6. PBTC-029 Phase I<br />
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

7. PBTC-029 Phase II: Primary Objectives
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

8. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Slide 8
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

9. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Slide 9
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

10. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Stratum 1: Recurrent/Refractory <br />BRAF Aberrant Pilocytic Astrocytoma
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

11. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Slide 11
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

12. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Slide 12
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

13. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Slide 13
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

14. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Slide 14
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

15. Stratum 1: Example of Radiographic Response<br />
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

16. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Stratum 1: Conclusions
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

17. Stratum 3: NF-1 associated <br />Low Grade Glioma
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

18. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Slide 18
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

19. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Slide 19
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

20. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Slide 20
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

21. Stratum 3: Example of Radiographic Response
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

22. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Stratum 3: Conclusions
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

23. Stratum 4: Non-NF-1-Associated Optic Pathway/Hypothalamic Tumors
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

24. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Toxicity
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

25. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Pharmacokinetics
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

26. Preliminary Conclusions and Future Directions
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting

27. Presented By Jason Fangusaro at 2017 ASCO Annual Meeting
Thank you
Presented By Jason Fangusaro at 2017 ASCO Annual Meeting