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Whole Exome Sequencing Reveals Severe Thrombophilia in Acute Unprovoked Idiopathic Fatal Pulmonary Embolism  Matt Halvorsen, Ying Lin, Barbara A. Sampson,

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Presentation on theme: "Whole Exome Sequencing Reveals Severe Thrombophilia in Acute Unprovoked Idiopathic Fatal Pulmonary Embolism  Matt Halvorsen, Ying Lin, Barbara A. Sampson,"— Presentation transcript:

1 Whole Exome Sequencing Reveals Severe Thrombophilia in Acute Unprovoked Idiopathic Fatal Pulmonary Embolism  Matt Halvorsen, Ying Lin, Barbara A. Sampson, Dawei Wang, Bo Zhou, Lucy S. Eng, Sung Yon Um, Orrin Devinsky, David B. Goldstein, Yingying Tang  EBioMedicine  Volume 17, Pages (March 2017) DOI: /j.ebiom Copyright © 2017 The Authors Terms and Conditions

2 Fig. 1 Odds ratios at the single gene level for pathogenic variant burden between cases and controls. For each gene, a depiction of the 95% confidence interval for the OR has been included. SERPINC1 appears to confer the highest PE risk amongst the three genes assessed. EBioMedicine  , DOI: ( /j.ebiom ) Copyright © 2017 The Authors Terms and Conditions

3 Fig. 2 Age-at-death for anticoagulant gene variant carriers versus non-carriers (a standard deviation has been included). EBioMedicine  , DOI: ( /j.ebiom ) Copyright © 2017 The Authors Terms and Conditions


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