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Stem Cell Marker Expression in Persistent Apical Periodontitis

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1 Stem Cell Marker Expression in Persistent Apical Periodontitis
Carlos Estrela, DDS, MSc, PhD, Brunno Santos Freitas Silva, DDS, MSc, PhD, Júlio A. Silva, DDS, MSc, PhD, Fernanda P. Yamamoto- Silva, DDS, PhD, Décio dos Santos Pinto-Júnior, DDS, MSc, PhD, Ricardo Santiago Gomez, DDS, MSc, PhD  Journal of Endodontics  Volume 43, Issue 1, Pages (January 2017) DOI: /j.joen Copyright © 2016 American Association of Endodontists Terms and Conditions

2 Figure 1 Immunohistochemical expression of CD90 in PAP specimens. (A) CD90 expression in inflammatory and mesenchymal cells in capsular tissue of a periapical cyst. (B) CD90 in chronic inflammatory cells (arrowhead) and mesenchymal cells (asterisk) of periapical granuloma. Magnification indicated in scale bar. Journal of Endodontics  , 63-68DOI: ( /j.joen ) Copyright © 2016 American Association of Endodontists Terms and Conditions

3 Figure 2 Comparative analysis of PAP and PPLs in relation to CD90 and Sox-2 expression (scores). *Statistically significant difference (Mann-Whitney U test, P < .05). Journal of Endodontics  , 63-68DOI: ( /j.joen ) Copyright © 2016 American Association of Endodontists Terms and Conditions

4 Figure 3 Immunohistochemical expression of Sox2 in PAP and PPLs. (A) Sox2 expression in odontogenic epithelial remnants (asterisk) and epithelial lining cells of PAP. (B) Sox2 expression in vascular endothelial cells of PAP. (C) Sox2 staining in chronic inflammatory cells (arrows) and in acute inflammatory cells (arrowheads) of a PAP sample. (D) Sox2 predominance in the presence of (E) acute inflammatory infiltrate compared with (F) chronic inflammatory infiltrate in PPLs. Magnification indicated in scale bar. Journal of Endodontics  , 63-68DOI: ( /j.joen ) Copyright © 2016 American Association of Endodontists Terms and Conditions


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