1. Secondee’s Report Work package 2 - Data mining Work package 3 – Imaging & data synthesis
A.Z. Khawaja
April 2015

2. Part I:. Personal background. Part II. Work Package 2 & 3. Part III
Part I: Personal background Part II Work Package 2 & Part III Future work Part IV IAAP - Courses, Training & Challenges Part V Future work

3. Personal Background: Primary medical qualification Hons. from
“Gr. T. Popa University, Iasi, Romania
Vascular surgery residency at Saint Spiridon University Hospital, Iasi, Romania
Trust grade in renal transplant and vascular access surgery at Queen Elizabeth Hospital Birmingham
IAAP ESR Fellowship to Guerbet Pharma, Paris (6months)

4. Personal Transfer of skills –
Contribution of clinical knowledge to IAAP workpackage 2 & 3
Acquire & improving research skills through knowledge exchange
Seconded from QEH Birmingham UK to industrial partner Guerbet Pharma in Paris (July 2014)
Supervisors - Dr Eric Lancelot & Mr Nick Inston
Fellow ESR secondees include:
Dr D.B. Cassidy & Mr J. Al Shakarchi
Guerbet colleagues: Javaad Ayub & Catarina Ramos

5. Work Package 2 Data Mining and Prospective Data Sharing
Evaluation of Evidence Base
Collate & analyse data on vascular access (VA)
Guidelines appraisal - Agree
Survey questionnaire - ReDVASQi
Clinical data sharing - Dundee & Birmingham

6. Quantitative appraisal of the guidelines (EBPG, KDOQI, CARI, CNS)
The Appraisal of Guidelines for REsearch & Evaluation (AGREE) Instrument II
Quantitative appraisal of the guidelines
(EBPG, KDOQI, CARI, CNS)
Ref: Brouwers M C., et al 2010, CMAJ ,

7. Survey Questionnaire on Imaging
Evaluation of current practice
Key Questions
Online Survey
ReDVA Pilot & UK wide

8. Work Package 3 Systematic review of evidence in literature
Imaging in vascular access
Ultrasound, DSA, CT, MRI
Diagnostic test accuracy
Intervention
Prognostic benefit

9. Two way exchange of knowledge
Benefits of IAPP network:
Literature data mining & data sharing
Questionnaire development & dissemination
Guideline appraisal & literature review
Insights into Industry:
Guerbet International, Medical & Regulatory Affairs meeting
Forming & strengthening collaborations:
Regional & National UK Centres
European Renal Association
Including doing a presentation

10. Future work
Generation of new knowledge / lack of from systematic reviews
Retrospective data collection - QEB, UoD and beyond
Clinical data mining – UK renal registry
Further validation of imaging techniques
Clinical study

11. Continuous professional development
European Vascular Course
Central Venous Access Devices
Endovascular foundations
Presentation & Interview Skills
Workshop on CO2 venography

12. Continuous professional development
Evidence based practice and critical appraisal of evidence
Research taster week - Presentation done for medical students
Workshop on methodology of systematic reviews
Interventional radiology trainee day
Cochrane systematic review of Diagnostic test accuracy (modular)
Medical & regulatory affairs

13. Publications
Assessing UK trends in vascular access imaging for haemodialysis patients – Results from ReDVASQi - A. Z. Khawaja, D.B. Cassidy, J. Al Shararchi, D. McGrogan, R.G. Jones, and N. Inston
AGREE instrument for assessment of current vascular access guidelines - D.B. Cassidy A. Z. Khawaja, J. Al Shararchi, D. McGrogan, R.G. Jones, and N. Inston
Re-visiting the risks of contrast enhanced MRI in vascular access imaging - A. Z. Khawaja, D.B. Cassidy, J. Al Shararchi, D. McGrogan, R.G. Jones, and N. Inston
Non-invasive three dimensional imaging for hemodialysis vascular access using magnetic resonance A. Z. Khawaja, D.B. Cassidy, J. Al Shararchi, D. McGrogan, R.G. Jones, and N. Inston
Current tools for prediction of arteriovenous fistula outcomes - Damian G. McGrogan; Alexander P. Maxwell; Aurang Z. Khawaja; Nicholas G. Inston
Vascular imaging to detect dialysis fistulas at risk of failurec review of diagnostic test accuracy, a Cochrane systemat – A. Z. Khawaja, D.B. Cassidy, S, Matthew, R.G. Jones, N. Inston and J.Houston

14. Presentations/Posters
  Assessing UK trends in vascular access imaging for haemodialysis patients – Results from ReDVASQi - A. Khawaja, D.B. Cassidy, J. Al Shararchi, D. McGrogan, R.G. Jones, and N. Inston
Re-visiting the risks of contrast enhanced MRI in vascular access imaging - A. Khawaja, D.B. Cassidy, J. Al Shararchi, D. McGrogan, R.G. Jones, and N. Inston
Early Experience With Viabahn Stent-Grafts To Treat Cephalic Arch Stenosis In Hemodialysis Patients With Ipsilateral Arteriovenous Fistulas – R Jones, PRiley, A Willis, NInston, A Khawaja
Performance of preterm prevention clinic – have we really made a difference? Karkhanis P, Malarselvi M, Khawaja A, Patni S, Sunanda G
Carbon dioxide as a contrast agent for in dialysis access intervention -A. Khawaja, RG. Jones, N. Inston, J. Hopkins
Cephalic arch vein disease in haemodialysis patients -U. Hayat, A. Khawaja, RG. Jones 
Outcomes of the haemodialysis reliable outflow device for vascular access -J. Al Shakarchi, A. Khawaja, D. McGrogan, RG. Jones, S. Powell, N. Inston 
Cephalic arch lesions in ipsilateral arteriovenous fistulas – Balloon or stent grafts? – S. Kharkhanis, A. Khawaja, A. Willis, P. Riely, R.G. Jones
Cutting Balloon Angioplasty in native AV fistulas – a seven year experience - A.Khawaja, RG. Jones, N. Inston, A. Willis, I. McCafferty, P.Riely 
Pre-operative examination for AV access in HD: an insight into clinical practise guidelines - DB. Cassidy, A. Khawaja, J. Ayub, N. Inston, EG. Lancelot, S. Matthew, JG. Houston

15. ReDVA Targets Background, systematic reviews & questionnaires
ERBP Collaboration - European guidelines & systematic reviews
Feedback & design of future clinical study protocols
Next stages: More questions to answer and translation
Primary and secondary outcomes

16. Personal goals – short term
Cochrane training modules
Collaborative systematic reviews
Harmonization and data acquisition
Inclusion of health economics
Continuous professional development

17. Personal goals – short term
Training in interventional radiology
Statistical methodology training
Develop teaching role
Attract prospective researchers – open days
Training in grant writing, management & sourcing further funding

18. Personal goals – long term
Translation of results to clinical trial
Implement beneficial change to management & clinical pathway
Strengthening collaboration - national & international
Develop long term clinical and academic role