1. Opioid-Induced Bowel Dysfunction
Jay Thomas, MD, PhD 
Journal of Pain and Symptom Management 
Volume 35, Issue 1, Pages (January 2008)
DOI: /j.jpainsymman
Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

2. Fig. 1
Anatomy of the GI system (adapted from: Shetzline and Liddle 20025).
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

3. Fig. 2
ICC interactions (LM=longitudinal muscle; CM=circular muscle; ICMP=myenteric plexus interstitial cells; ICIM=intramuscular interstitial cells; ICSM=submucosal interstitial cells) (adapted from: Cook and Brookes, 20027).
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

4. Fig. 3 Chemical structure of alvimopan.
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

5. Fig. 4 Chemical structure of methylnaltrexone.
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions