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Patterns of Inheritance
A Summary
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Autosomal Dominant & Recessive
Autosomes are all chromosomes other than the pair that determines sex. Dominant alleles are expressed in the phenotype. Recessive alleles are not expressed in the phenotype unless they are homozygous.
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Incomplete Dominance In incomplete dominance, the phenotype of a heterozygous individual is intermediate between the phenotypes of the two homozygous phenotypes.
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CR CW Cw CR CR CR CW CW CW White CWCW Red CRCR Pink CRCW 1⁄2 Sperm
P Generation F1 Generation F2 Generation Red CRCR Gametes CR CW White CWCW Pink CRCW Sperm Cw 1⁄2 Eggs CR CR CR CW CW CW
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Whippet Phenotypes Normal Whippet M+M+ “Fast” Whippet M+M- “Bully” Whippet M-M-
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Normal, “Fast”, and “Bully” Whippets
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Wendy, the Bully Whippet
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“Fast” Whippet x “Fast” Whippet
M+M- x M+M- M+ M- M+M+ M+M- M-M- Genotype ratio 1 : 2 : 1 Phenotype ratio 1 : 2 : 1 (Normal : Fast : Bully)
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Autosomal Codominance
In codominance, two different alleles are equally expressed in the phenotype.
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Polygenic Traits Some traits are affected by many genes.
Such traits are said to be polygenic. Polygenic traits often vary continuously, instead of in an “either / or” fashion. Body size, skin color, hair color, and eye color are polygenic.
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A Simplified Model of Polygenic Control of Skin Color
AaBbCc aabbcc Aabbcc AaBbcc AABbCc AABBCc AABBCC 20⁄64 15⁄64 6⁄64 1⁄64 Fraction of progeny
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X-Linked Inheritance Sex is determined by the last pair of chromosomes, designated X and Y XX genotype = female XY genotype = male Male parents pass the X chromo to female children, the Y to male children. Females pass one or the other X to both male and female children.
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Some Additional Patterns
(not covered in our course)
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Mitochondrial DNA Mitochondria have their own DNA chromosome.
Mitochondrial traits can be passed through the mother only, because the zygote contains only mitochondria from the ovum.
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Affected Mother XY XcY XXc XcXc XX
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Epistasis One gene affects the expression of a second gene BC bC Bc
1⁄4 BBCc BbCc BBcc Bbcc bbcc bbCc BbCC bbCC BBCC 9⁄16 3⁄16 4⁄16 Sperm Eggs One gene affects the expression of a second gene
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