1. ANIMAL GROWTH AND DEVELOPMENT

2. Introduction Growth and development have important implications for domestic animal production because they significantly influence the value of the animal being produced. Photo by Keith Weller courtesy of USDA Agricultural Research Service.

3. A substantial proportion of agricultural research focuses on how to make animal growth and development processes more efficient. This research involves several disciplines because animal growth and development are controlled by genes and hormones.

4. Because growth and development are continuous and dynamic processes requiring integration of numerous physiological functions, they are influenced by:

5.  nutrition,  efficiency of metabolism and respiration,  hormonal regulation,  immune response,  physiological status of the animal,  diseases and parasites,  maintenance of homeostasis.

6. Animal growth and development can be separated into processes occurring before birth or hatching (pre-natal) and those occurring after birth or hatching (post-natal).

7. Pre-Natal Growth and Development Pre-natal growth and development are broken down into two stages: 1-Embryogenesis 2-Organogenesis

8. 1-Embryogenesis extends from the union of female and male gametes to the emergence of the embryonic axis and development of organ systems at the neurula stage. During embryogenesis, the zygote develops into the morula, which becomes the blastula and then the gastrula.

9. Cleavage is a process that involves mitotic division of the original cell into two cells, which then divide in to four cells and then eight cells.

10. 2-Organogenesis The process of organogenesis extends from the neurela stage to birth or hatching. The neurela stage is distinguished by differentiation, which is when unspecialized embryonic cells change into specialized cells destined to form specific tissues or organs.

11. The process of organogenesis Differentiation starts at the upper surface to the gastrula. Cells of the ectoderm divide and form the neural plate. Two raised edges or neural folds appear and gradually come together to form the neural tube.

13. A mass of cells called the neural crest is pinched off the top of the neural tube Eventually, the front part of the neural tube thickens and forms the brain; the remainder of the tube becomes the spinal cord. In the first few weeks after conception, cells differentiate into organs and body structures. The embryo is then referred to as a fetus and the body structures continue to grow and develop until birth.

15. PRENATAL GROWTH – Factors affecting size at birth: Number of young born. Size of the dam. Age of the dam. Sex of the litter members. Level of nutrition.

16. Post-Natal Growth The period of post-natal growth extends from birth or hatching until death.The length of this period depends greatly on the species.

17. The average life span of a mouse is about 2 years, while humans and elephants live to be well over 60 years of age. Sheep and cattle tend to live to be around 15 and 30 years of age, respectively. Muscle, bone, and fat are the three main types of tissues that develop as an animal grows.

18. The rate of deposition depends on the age of the animal and the type of tissue being deposited. Muscle fibers are formed from multiple cells called myoblasts. While the animal is still in the prenatal stage, myoblasts fuse together to form a myotube, which develops into a muscle fiber. As a result, one muscle fiber has multiple nuclei.

19. POSTNATAL GROWTH – Factors affecting growth: Size of the animal at birth. Sex of the animal. Breed Environment Genetics Nutrition

20. Hormonal Control Deposition of different tissues and partitioning of energy for various processes involved in growth and development are regulated by hormones.

21. Insulin Insulin is a very important hormone involved in muscle growth and development. It stimulates the transport of certain amino acids into muscle tissue and is active in reducing the rate of protein degradation.

22. Growth Hormone Growth hormone stimulates protein anabolism in many tissues. This effect reflects increased amino acid uptake, increased protein synthesis, and decreased oxidation of proteins.

24. Insulin-like Growth Factor 1 IGF-1 stimulates proliferation of chondrocytes (cartilage cells), thus resulting in bone growth.It is also important in protein, fat, and carbohydrate metabolism.

25. Thyroid Hormones Animals require thyroid hormones for normal growth.Deficiencies of T 4 (thyroxine) and T 3 (tri- iodothyronine) cause reduced growth as a result of decrease muscle synthesis and increased proteolysis

26. Glucocorticoids Glucocorticoids restrict growth and induce muscle wasting; they have different effects on different types of muscle.Some evidence indicates that glucocorticoids also effect metabolic rate and energy balance.

28. Steroids Androgens (male sex hormones) have an obvious effect on muscle development and growth in general because male animals grow faster and develop more muscle than do females

30. Genetic Control Most processes involved in growth and development are occurring at a cellular level.Because this is such a finite level, it can be difficult to control or manipulate these processes outside of a scientific laboratory.

31. Growth of muscle and fat The growth of tissues consists of two processes. First, the number of cells increases by cell division. This is referred to as hyperplasia. Second, the cells increase in size. This is referred to as hypertrophy. Most of the hyperplasia occurs before birth.

32. Muscle growth The cells that will form muscle fibres are called myoblasts. Each has a single nucleus. The myoblasts fuse into muscle ‘straps’ which subsequently lose their separate cell membranes to form multinucleated myotubes. These are immature muscle fibres.

33. Fat growth Fat occurs in a specialized connective tissue called adipose tissue. Fat cells are referred to as adipocytes. Their size differs in different fat depots and at different stages of growth. The proportion of the total body fat in each fat depot varies between species. For example, cattle and sheep have proportionally more abdominal fat and less subcutaneous fat than pigs.