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Treatment response to unboosted atazanavir in combination with tenofovir disoproxil fumarate and lamivudine in human immunodeficiency virus-1-infected.

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Presentation on theme: "Treatment response to unboosted atazanavir in combination with tenofovir disoproxil fumarate and lamivudine in human immunodeficiency virus-1-infected."— Presentation transcript:

1 Treatment response to unboosted atazanavir in combination with tenofovir disoproxil fumarate and lamivudine in human immunodeficiency virus-1-infected patients who have achieved virological suppression: A therapeutic drug monitoring and pharmacogenetic study  Mao-Song Tsai, Sui-Yuan Chang, Shu-Wen Lin, Ching-Hua Kuo, Hsin-Yun Sun, Bin-Ru Wu, Sue-Yo Tang, Wen-Chun Liu, Yi-Ching Su, Chien-Ching Hung, Shan-Chwen Chang  Journal of Microbiology, Immunology and Infection  Volume 50, Issue 6, Pages (December 2017) DOI: /j.jmii Copyright © Terms and Conditions

2 Figure 1 Time-to-virological failure in patients who switched to unboosted atazanavir plus two nucleos(t)ide reverse-transcriptase inhibitors (tenofovir-based vs. non-tenofovir-based regimens). TDF = tenofovir disoproxil fumarate. Journal of Microbiology, Immunology and Infection  , DOI: ( /j.jmii ) Copyright © Terms and Conditions

3 Figure 2 Plasma atazanavir concentrations, tenofovir/lamivudine + unboosted atazanavir, and abacavir-lamivudine (or zidovudine-lamivudine) + unboosted atazanavir. Journal of Microbiology, Immunology and Infection  , DOI: ( /j.jmii ) Copyright © Terms and Conditions

4 Figure 3 Forest plot showing the risk of virological failure according to subgroups. CI = confidence interval; MDR1 = multidrug resistance 1; PXR = pregnane X receptor. Journal of Microbiology, Immunology and Infection  , DOI: ( /j.jmii ) Copyright © Terms and Conditions

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