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From: Propofol Attenuates Peroxynitrite-mediated DNA Damage and Apoptosis in Cultured Astrocytes:An Alternative Protective Mechanism Anesthes. 2004;101(6): Figure Legend: Fig. 2. Comet assay of genomic DNA of rat astrocytes. Tail moments were quantified using Scion Image software. Values are mean ± SD of four experiments performed in duplicate ( A ). * Statistically significant versus control, P < 0.001; ** statistically significant versus propofol + 3 mm SIN-1, P < 0.001). Astrocytes were treated for 24 h with propofol or a corresponding amount of Intralipid (40 μm, 80 μm, 160 μm, and 1 mm) ( B ) and SIN-1 at different concentrations (1, 2, and 3 mm) ( C ). D , E , F , and G show the protective effects of propofol and Intralipid in SIN-1 (3 mm)–treated astroglial cells. Arrows indicate comet tails. SnMP = tin mesoporphyrin. Date of download: 12/16/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.
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