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Figure 1. Frailty components in mice vs humans.

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Presentation on theme: "Figure 1. Frailty components in mice vs humans."— Presentation transcript:

1 Figure 1. Frailty components in mice vs humans.
From: A New Frailty Score for Experimental Animals Based on the Clinical Phenotype: Inactivity as a Model of Frailty J Gerontol A Biol Sci Med Sci. 2017;72(7): doi: /gerona/glw337 J Gerontol A Biol Sci Med Sci | © The Author Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please

2 Figure 2. Unintentional weight loss
Figure 2. Unintentional weight loss. Animals’ body weights were recorded throughout their lifespan. When an animal lost more than 5% of the weight at age 17, we considered that it was frail for this parameter. Data are expressed as percentage of mice that did not lose more than the 5% of body weight in the sedentary (S) and wheel-runners’ (WR) groups. The number of animals tested was 5 in all the experimental groups and ages (17, 20, 23, 26 and 28 months). Statistical differences were tested using Pearson’s chi-squared test. From: A New Frailty Score for Experimental Animals Based on the Clinical Phenotype: Inactivity as a Model of Frailty J Gerontol A Biol Sci Med Sci. 2017;72(7): doi: /gerona/glw337 J Gerontol A Biol Sci Med Sci | © The Author Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please

3 Figure 3. Weakness. Reference mice grip strength values at the different ages were obtained. Data are expressed as percentage of mice that did not fulfill this frailty criterion. The number of animals tested were: 17 m (60S and 60WR), 20 m (50S, 46 WR), 23 m (44S, 45WR), 26 m (22S, 27WR), 28 m (11S, 11WR). Statistical differences were tested using Pearson’s chi-squared test. From: A New Frailty Score for Experimental Animals Based on the Clinical Phenotype: Inactivity as a Model of Frailty J Gerontol A Biol Sci Med Sci. 2017;72(7): doi: /gerona/glw337 J Gerontol A Biol Sci Med Sci | © The Author Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please

4 Figure 4. Poor endurance and slowness
Figure 4. Poor endurance and slowness. We determined the reference running time (A) and running speed (B) values at the different ages in our mice. Data are expressed as the percentage of mice that did not fulfill these frailty criteria. The number of animals tested were: 17m (9S, 10WR), 20m (13S, 13WR), 23m (10S, 8WR), 26m (10S, 10WR). Statistical differences were tested using Pearson’s chi-squared test. From: A New Frailty Score for Experimental Animals Based on the Clinical Phenotype: Inactivity as a Model of Frailty J Gerontol A Biol Sci Med Sci. 2017;72(7): doi: /gerona/glw337 J Gerontol A Biol Sci Med Sci | © The Author Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please

5 Figure 5. Motor coordination
Figure 5. Motor coordination. It was determined as the percentage of animals that successfully passed the tightrope test at the different ages. The number of animals tested were 17m (12S, 12WR), 20m (12S, 12WR), 23m (20S, 20WR), 26m (24S, 23WR), 28 m (12S, 11WR). Statistical differences were tested using Pearson’s chi-squared test. From: A New Frailty Score for Experimental Animals Based on the Clinical Phenotype: Inactivity as a Model of Frailty J Gerontol A Biol Sci Med Sci. 2017;72(7): doi: /gerona/glw337 J Gerontol A Biol Sci Med Sci | © The Author Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please

6 Figure 6. Frailty score in mice
Figure 6. Frailty score in mice. The frailty score for each age group of animals was calculated as follows: total number of test failed by the animals at each age group divided by the total number of tests performed by these animals, expressed in percentage. Statistical differences were tested using Pearson’s chi-squared test. From: A New Frailty Score for Experimental Animals Based on the Clinical Phenotype: Inactivity as a Model of Frailty J Gerontol A Biol Sci Med Sci. 2017;72(7): doi: /gerona/glw337 J Gerontol A Biol Sci Med Sci | © The Author Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please

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