1. Dr. Kristine lokken Functional neuropsychologist
Co-founder/ceo brain health Institute, Inc
Director of rehabilitation neuropsychology, birmingham vamc
Assistant professor, department of psychology, uab
Clinical assistant professor, department of psychiatry and behavioral Neurobiology, UAB

2. Preventing and Treating Cognitive Decline: A Different Approach
PRESENTED AT THE:
Alzheimer’s of Central Alabama
2017 Annual Conference
Tuesday, October 17, 2017
Canterbury United Methodist Church

3. Learning objectives
Participants will gain basic knowledge of effective strategies for preventing and treating cognitive decline
Participants will be introduced to the brainH.E.A.L.T.H.TM model of intervention
Participants will walk away with practical tips, tools, and information to transform fear and resignation into hope and determination

5. Impact. Changing the landscape on how we view and treat AD
Power of One
Direct
Patient Quality of Life
Patient Functional Abilities
Indirect
Spouse, family risk and caregiver burden
Medical and Long-term Care Cost
Global Impact of Dementia: Financial and Emotional

7. POINTS OF INTERVENTION
Prevention
Before any cognitive symptoms are detected
Targeting those with APOE 4 genetic marker
Restoration
Subjective Cognitive Impairment (SCI)
Mild Cognitive Impairment (MCI)
Early Alzheimers Disease (AD)/Other Neurological Disorder (FTD, VAD, etc)
Stablization
When disease process has taken hold
Cognitive, mood, quality of life

8. A different approach Getting at the Root Cause
Personalized Adjuncts To Standard Conventional Therapy
Systems Biology Approach - OPTIMIZATION
Regulation of mood, stress, eating behaviors, dietary selection, and sleep
Incorporating Targeted Exercise
Cognitive Rehabilitation
Reducing Toxicant Exposure Load

9. GETTING TO THE ROOT CAUSE
Functional Medicine
Asks how and why illness occurs
Interpret Symptoms as a Message
Reason for Amyloid
Work by Bredesen
Gut-Brain Connection
Work by Perlmutter

10. ”Doctor, my toe hurts!”

11. Functional Medicine Approach
One condition, Many Causes
One Cause, Many conditions
Alzheimers
Disease
Inflammation
Infections
Cancer
Heart
Disease
ALZHEIMERS
DISEASE
Hormones
INFLAMMATION
Toxicants
Depression
Type 3 DM
Arthritis

12. Many underlying causes of memory impairment
Seek an excellent work-up to confirm diagnosis
Seek to personalize your treatment
A one-size fits all approach does not work
There is no silver bullet – so try for silver buckshot
36+ points of intervention (Based on Bredesen Protocol)

13. 36+ Points of Intervention
Systems Biology Approach - OPTIMIZATION
Regulation of mood, stress, eating behaviors, dietary selection, and sleep
Incorporating Targeted Exercise
Cognitive Rehabilitation
Reducing Toxicant Exposure Load
EASY
MOD
HARD
Vit D
Int Fasting
Sleep
Hormones
Keto Diet
Exercise

14. brainH.E.A.L.T.H.TM Intervention
H = HEALTHY EATING
E = EMOTIONAL REGULATION
A = ACTIVITY
L = LEARNING STRATEGIES
T = TOXICANT REDUCTION
H = HABITS

15. brainH.E.A.L.T.H.TM Intervention
From SAD to KETO
(and the many iterations in between)
Begin by ridding of sugar (all forms), artificial sugars, processed food, processed carbohydrates
Contributes to inflammation
Diabetes Type 3
Incorporate Intermittent Fasting
Ketones provide alternate fuel source
Begin to limit carbohydrates and increase healthy fats
Needs to be medically supervised
H = HEALTHY EATING
E = EMOTIONAL REGULATION
A = ACTIVITY
L = LEARNING STRATEGIES
T = TOXICANT REDUCTION
H = HABITS

16. brainH.E.A.L.T.H.TM Intervention
Interventions for overt emotional issues (Anxiety, Depression, Other Psychological Disorders)
Role of Cortisol on Brain Function
”STRESS” Management
Techniques
Meditation
fMRI Studies
Memory Studies
brainH.E.A.L.T.H.TM Intervention
H = HEALTHY EATING
E = EMOTIONAL REGULATION
A = ACTIVITY
L = LEARNING STRATEGIES
T = TOXICANT REDUCTION
H = HABITS

17. brainH.E.A.L.T.H.TM Intervention
Exercise
Isometric
Movement
Cardiovascular
Stretching/Yoga/Pilates
Restorative Sleep
Sex
Joy
Meaning and Purpose
H = HEALTHY EATING
E = EMOTIONAL REGULATION
A = ACTIVITY
L = LEARNING STRATEGIES
T = TOXICANT REDUCTION
H = HABITS

18. brainH.E.A.L.T.H.TM Intervention
Neuropsychological Testing
Specific strengths and weaknesses
Emphasize the strengths, challenge the weaknesses
BrainHQ and other brain training programs
Individual Cognitive Rehabilitation
Self-challenging Activities
Video Clip
H = HEALTHY EATING
E = EMOTIONAL REGULATION
A = ACTIVITY
L=LEARNING STRATEGIES
T = TOXICANT REDUCTION
H = HABITS

19. brainH.E.A.L.T.H.TM Intervention
Environmental Exposures
Water
Mold
Heavy Metals
Health and Beauty Aids
No federal law since 1938
Environmental Working Group
Skin Deep (ewg.org or EWG Healthy Living App)
H = HEALTHY EATING
E = EMOTIONAL REGULATION
A = ACTIVITY
L = LEARNING STRATEGIES
T=TOXICANT REDUCTION
H = HABITS

20. brainH.E.A.L.T.H.TM Intervention
“I did then what I knew
how to do. Now that I
know better, I do better.”
― Maya Angelou
brainH.E.A.L.T.H.TM Intervention
H = HEALTHY EATING
E = EMOTIONAL REGULATION
A = ACTIVITY
L = LEARNING STRATEGIES
T = TOXICANT REDUCTION
H = HABITS
Knowledge has little power
without implementation
Begin with a good night’s sleep
Then with a good breakfast
Then a good morning routine
….and so on
Continue in incremental steps until
that criticial threshold is met

21. Emotional Regulation HEALTHY EATING Activity
Participants will walk away with practical tips, tools, and information to transform fear and resignation into hope and determination
Emotional Regulation
HEALTHY EATING
Activity
Avoid Proc Carbs
Avoid Sugar
Easy
Add Healthy Fats
Clean Protien
Mod
No Sugar
Alkaline Keto Diet
Hard Rx
Supplements
Easy
Self Care
Remove Stressors
Mod
Meditate Daily
Change Response
Hard
Add Movement
Isometrics
Easy
8 hrs restful sleep
Cardio/Yoga/Wts
Mod
Meaning & Purpose
Tabata/HIIT
Hard

22. Toxicant removal LEArning Strategies Habits
Participants will walk away with practical tips, tools, and information to transform fear and resignation into hope and determination
Toxicant removal
LEArning Strategies
Habits
Brain HQ
Use it!
Easy
Cog Rehab
Actively Engage
Mod
Self-Challenges
Learn New Skills
Hard
Water Filters
Swap HBA’s
Easy
Check Home, etc
Detox (Pizzorno)
Mod
Fx Med Workup
Invest in Treatment
Hard
Sleep Schedule
Intermittent Fast
Easy
Good Breakfast
Morn/Eve Routines
Mod
Daily Schedule
Trouble Shooting
Hard

23. Contact Info: Dr. Kristine Lokken .com tele#
LOCATION: Independence Drive, Suite 114
Homewood, AL 25309