1. Pathways involved in oxalate, glyoxylate, and glycolate metabolism in the human hepatocyte. Peroxisomal enzymes: (1) L-2-hydroxy acid oxidase A/glycolate oxidase (EC ), (2) catalase (EC ), (3) D-amino acid oxidase/glycine oxidase (EC ), and (4) alanine:glyoxylate aminotransferase/serine:pyruvate aminotransferase (EC / ). Cytosolic enzymes: (5) lactate dehydrogenase (EC ), (6) D-glycerate dehydrogenase/glyoxylate reductase (EC / / ), (7) hydroxypyruvate decarboxylase (EC ) (also occurs in the mitochondria231 ), (8) aldehyde dehydrogenase (EC ) (various isoforms are also found in other intracellular compartments, such as mitochondria, peroxisomes, and microsomes551 ), (9) glycolate dehydrogenase (EC ), (10) glutamate:glyoxylate aminotransferase/alanine:2-oxoglutarate aminotransferase (EC / ), (11) serine hydroxymethyltransferase (EC ), and (12) serine dehydratase (EC ). PyrP, pyridoxal phosphate; FAD, flavin-adenine dinucleotide; FMN, flavin mononucleotide; NAD(P)+/NAD(P)H, oxidized and reduced forms of nicotinamide-adenine dinucleotide (phosphate). Note that the relative importance of the various metabolic pathways is not universally agreed on (see text for details).
Source: Primary Hyperoxaluria, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: December 16, 2017
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