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HISTORY OF BIOORGANIC CHEMISTRY
Diana Tulegenova
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Dr. Margaret Belle (Oakley) Dayhoff founder of biorganic chemistry The one-letter code used for amino acids was developed by her, reflecting an attempt to reduce the size of the data files used to describe amino acid sequences in an era of punch-card computing.
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In the early 1950s the development of increasingly sophisticated methods to detect and determine structures of organic molecules were applied to biological systems. Konrad Bloch and Feodor Lynen pioneered the use of radioisotopes in their studies that led to their discovery of the mevalonate pathway for biosynthesis of cholesterol from acetic acid.
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As connections between genes and nucleic acids, enzymes and proteins, were established by geneticists and biochemists in the 1930s and 1940s, a group of chemists and physicists became increasingly interested in the structures of these substances with the ultimate goal of understanding fundamental biological processes at the molecular level.
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Molecules from nature were indespensible tools as generations of organic chemists developed new techniques for determining structures, analyzed the mechanisms of reactions, explored the effects conformation and stereochemistry on reactions, and found challenging new targets to synthesize.
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Зимон А. Д.; коллоидная химия наночастиц
Patent US Atomic force microscope and method for imaging surfaces with atomic resolution Cappella, B; Dietler, G (1999). "Force-distance curves by atomic force microscopy“
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