1. World Health Organization
25 August, 2018
Access to medicines:
Antimalarials
WHO / UNICEF TBS - Access to Medicines
19 November 2008, Geneva
Silvia Schwarte Global Malaria Programme

2. World Health Organization
Outline
25 August, 2018
WHO MTG – Policy – Procurement
Funding
Paediatric antimalarial medicine
Quality
Monotherapy ban

3. World Health Organization
ACTs: policy adoption, deployment, past procurement and 2008/09 forecast
World Health Organization
25 August, 2018
Forecast
Millions of ACT treatment courses
6-24 months from
adoption to deployment
Cumulative number of countries

4. Increasing resources for ACTs
World Health Organization
Increasing resources for ACTs
25 August, 2018
Round 7 GFATM approved 62% of malaria grants, and Round 8 approved 68% of malaria grants
UNITAID: new funding for AIDS, TB and malaria medicines
Affordable Medicine Facility for malaria (AMFm) – GFATM approved initial roll-out plan for 11 countries to start in April 09
Successful applications to
GFATM Round 6, 7 and 8
Millions USD

5. Children's medicines: specific requirements
World Health Organization
Children's medicines: specific requirements
25 August, 2018
Correct dosing: extrapolating information obtained with adults or fractioning of adult dosage may be inadequate => need for appropriate dose-finding studies
Ease of administration: taste, colour, flavour – but cave: excipients alcohol, sugar shall be avoided grant stability while certain preservative cannot be used in children
Choose suitable formulations: Liquid: syrups, solutions, suspensions – stability, reconstitution Semi-solid: suppositories – heat stability, pre-referral treatment (MTG 2006) Solid: (easy breakable or dispersible) tablets, capsules, granules, pellets
Affordable price despite higher development costs
Supply Chain issues (volume, transport and storage costs, distribution)

6. World Health Organization
25 August, 2018
Co-blister
Fixed-dose
Co-bl.

7. World Health Organization
25 August, 2018
Manufacturers of oral artemisinin monotherapies
12/68 (18%) withdrew their products
22/68 (32%) intend to comply with WHO ban
Number of
companies
Substandard
medicines?

8. World Health Organization
25 August, 2018
Thank you