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C. As the result of an MS plaque involving the posterior columns of the cervical cord, patients may experience an electric shock-like sensation traveling down the spine and possibly into the limbs when the examiner flexes the neck (L'hermitte sign). Because MS is a disease of central white matter, lesions may cause upper motor neuron signs, such as brisk reflexes or a Babinski sign. Source: The Neurological Examination of the Patient, Principles of Neural Science, Fifth Editon Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available at: Accessed: December 17, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
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