1. Relationship of Down syndrome to maternal age
Relationship of Down syndrome to maternal age. The frequency of Down syndrome rises exponentially with increasing maternal age. The frequency at amniocentesis (blue symbols) is slightly higher than in live-born infants (black symbols) because miscarriages are more likely in fetuses with Down syndrome. (Data from Scriver CR et al, eds. The Metabolic and Molecular Bases of Inherited Disease, 8th ed. McGraw-Hill, 2001.)
Source: Genetic Disease, Pathophysiology of Disease: An Introduction to Clinical Medicine, 7e
Citation: Hammer GD, McPhee SJ. Pathophysiology of Disease: An Introduction to Clinical Medicine, 7e; 2013 Available at: Accessed: December 17, 2017
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