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Ten-year trends in prevalence of Down syndrome in a developing country: impact of the maternal age and prenatal screening  Amina Kurtovic-Kozaric, Lejla.

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Presentation on theme: "Ten-year trends in prevalence of Down syndrome in a developing country: impact of the maternal age and prenatal screening  Amina Kurtovic-Kozaric, Lejla."— Presentation transcript:

1 Ten-year trends in prevalence of Down syndrome in a developing country: impact of the maternal age and prenatal screening  Amina Kurtovic-Kozaric, Lejla Mehinovic, Radmila Malesevic, Semir Mesanovic, Tijana Jaros, Meliha Stomornjak-Vukadin, Mirela Mackic-Djurovic, Slavica Ibrulj, Ilvana Kurtovic-Basic, Mirza Kozaric  European Journal of Obstetrics and Gynecology and Reproductive Biology  Volume 206, Pages (November 2016) DOI: /j.ejogrb Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Total numbers of T21 cases diagnosed prenatally and postnatally from 2005 to (A and B) Annual distribution of T21 cases diagnosed prenatally (gray bars) and postnatally (black bars) in Bosnia and Herzegovina. European Journal of Obstetrics and Gynecology and Reproductive Biology  , 79-83DOI: ( /j.ejogrb ) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Total (gray) and LB prevalence (black) per 10,000 births of trisomy 21, in the period from 2005 to 2015. European Journal of Obstetrics and Gynecology and Reproductive Biology  , 79-83DOI: ( /j.ejogrb ) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 T21 total and LB prevalence per 10,000 births for Bosnia and Herzegovina, Europe [7] and USA [8]. European Journal of Obstetrics and Gynecology and Reproductive Biology  , 79-83DOI: ( /j.ejogrb ) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

5 Fig. 4 The effect of maternal age on T21 distribution. (A) The distribution of T21 pregnancies by maternal age. (B) Prenatal prevalence per 10,000 births (log scale) of T21 by maternal age. European Journal of Obstetrics and Gynecology and Reproductive Biology  , 79-83DOI: ( /j.ejogrb ) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

6 Fig. 5 Distribution of the most common indications for prenatal invasive testing. US—ultrasound screening; B—biochemical maternal serum screening; AMA—advanced maternal age. Other—family history, mother’s anxiety, and other reasons. European Journal of Obstetrics and Gynecology and Reproductive Biology  , 79-83DOI: ( /j.ejogrb ) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions


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